ID A0A1S2THJ6_9GAMM Unreviewed; 153 AA.
AC A0A1S2THJ6; A0A380BG96;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ {ECO:0000256|HAMAP-Rule:MF_00406};
DE EC=4.2.1.59 {ECO:0000256|HAMAP-Rule:MF_00406};
DE AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase {ECO:0000256|HAMAP-Rule:MF_00406};
DE Short=(3R)-hydroxymyristoyl-ACP dehydrase {ECO:0000256|HAMAP-Rule:MF_00406};
DE AltName: Full=Beta-hydroxyacyl-ACP dehydratase {ECO:0000256|HAMAP-Rule:MF_00406};
GN Name=fabZ_2 {ECO:0000313|EMBL:SUJ00096.1};
GN Synonyms=fabZ {ECO:0000256|HAMAP-Rule:MF_00406,
GN ECO:0000313|EMBL:KAB7512218.1};
GN ORFNames=E1N14_00845 {ECO:0000313|EMBL:KAB7512218.1}, E1N14_015260
GN {ECO:0000313|EMBL:QTE76878.1}, NCTC10738_03025
GN {ECO:0000313|EMBL:SUJ00096.1};
OS Shewanella algae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Shewanellaceae; Shewanella.
OX NCBI_TaxID=38313 {ECO:0000313|EMBL:SUJ00096.1, ECO:0000313|Proteomes:UP000254069};
RN [1] {ECO:0000313|EMBL:SUJ00096.1, ECO:0000313|Proteomes:UP000254069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC10738 {ECO:0000313|EMBL:SUJ00096.1,
RC ECO:0000313|Proteomes:UP000254069};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:KAB7512218.1, ECO:0000313|Proteomes:UP000325940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CECT 5071 {ECO:0000313|EMBL:KAB7512218.1,
RC ECO:0000313|Proteomes:UP000325940};
RA Thorell K., Rodriguez J.M., Sjoling A.;
RT "Resequencing of Shewanella algae Type Strain.";
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:QTE76878.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CECT 5071 {ECO:0000313|EMBL:QTE76878.1};
RA Martin-Rodriguez A.J.;
RT "Comparative genomics of Shewanella algae.";
RL Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC saturated and unsaturated beta-hydroxyacyl-ACPs.
CC {ECO:0000256|ARBA:ARBA00025049, ECO:0000256|HAMAP-Rule:MF_00406}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O;
CC Xref=Rhea:RHEA:13097, Rhea:RHEA-COMP:9925, Rhea:RHEA-COMP:9945,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:78784, ChEBI:CHEBI:78827; EC=4.2.1.59;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00406};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_00406}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC subfamily. {ECO:0000256|ARBA:ARBA00009174, ECO:0000256|HAMAP-
CC Rule:MF_00406}.
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DR EMBL; SMNR01000001; KAB7512218.1; -; Genomic_DNA.
DR EMBL; CP068230; QTE76878.1; -; Genomic_DNA.
DR EMBL; UGYO01000002; SUJ00096.1; -; Genomic_DNA.
DR RefSeq; WP_025010987.1; NZ_UGYO01000002.1.
DR AlphaFoldDB; A0A1S2THJ6; -.
DR STRING; 38313.GCA_000947195_03052; -.
DR GeneID; 72199847; -.
DR KEGG; salg:BS332_00560; -.
DR OrthoDB; 9772788at2; -.
DR Proteomes; UP000254069; Unassembled WGS sequence.
DR Proteomes; UP000325940; Chromosome.
DR Proteomes; UP000325940; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019171; F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR CDD; cd01288; FabZ; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR HAMAP; MF_00406; FabZ; 1.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR010084; FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR NCBIfam; TIGR01750; fabZ; 1.
DR PANTHER; PTHR30272:SF1; (3R)-HYDROXYMYRISTOYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE; 1.
DR PANTHER; PTHR30272; 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE; 1.
DR Pfam; PF07977; FabA; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00406};
KW Lipid A biosynthesis {ECO:0000256|ARBA:ARBA00022556, ECO:0000256|HAMAP-
KW Rule:MF_00406};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516, ECO:0000256|HAMAP-
KW Rule:MF_00406};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098, ECO:0000256|HAMAP-
KW Rule:MF_00406};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00406};
KW Reference proteome {ECO:0000313|Proteomes:UP000254069}.
FT ACT_SITE 54
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00406"
SQ SEQUENCE 153 AA; 17318 MW; 47180D9AA396A043 CRC64;
MSNQLNTMDI KEILAYLPHR YPFLLIDRVL DFTPGETLHA IKNVTINEPF FQGHFPVQPV
MPGVLILEAM AQATGLLAFK TMSDKPSPDV LYYFAGIDNA RFKRVVEPGD QLHFEVKMIK
ERRGIGVFYG EAKVDGELVC SAEIMCARRE ISK
//