ID A0A1S2WYW7_SALSA Unreviewed; 559 AA.
AC A0A1S2WYW7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE SubName: Full=hepatocyte nuclear factor 1-alpha {ECO:0000313|RefSeq:NP_001117146.1};
GN Name=hnf1a {ECO:0000313|RefSeq:NP_001117146.1};
GN Synonyms=hnf1 {ECO:0000313|RefSeq:NP_001117146.1}, tcf1
GN {ECO:0000313|RefSeq:NP_001117146.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:NP_001117146.1};
RN [1] {ECO:0000313|RefSeq:NP_001117146.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=7897653; DOI=10.1006/jmbi.1994.0115;
RA Deryckere F, Byrnes L, Wagner A, McMorrow T, Gannon F;
RT "Salmon HNF1: cDNA sequence, evolution, tissue specificity and binding to
RT the salmon serum albumin promoter.";
RL J. Mol. Biol. 247:1-10(1995).
RN [2] {ECO:0000313|RefSeq:NP_001117146.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA Koop B.F.;
RT "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT evolutionary pressures on a post-tetraploidization genome.";
RL BMC Genomics 11:279-279(2010).
RN [3] {ECO:0000313|RefSeq:NP_001117146.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the HNF1 homeobox family.
CC {ECO:0000256|ARBA:ARBA00009966}.
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DR RefSeq; NP_001117146.1; NM_001123674.1.
DR AlphaFoldDB; A0A1S2WYW7; -.
DR SMR; A0A1S2WYW7; -.
DR GeneID; 100136586; -.
DR KEGG; sasa:100136586; -.
DR CTD; 6927; -.
DR OrthoDB; 5398560at2759; -.
DR Proteomes; UP000087266; Chromosome ssa20.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030073; P:insulin secretion; IEA:InterPro.
DR GO; GO:0001889; P:liver development; IEA:InterPro.
DR GO; GO:0031016; P:pancreas development; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR039066; HNF-1.
DR InterPro; IPR006899; HNF-1_N.
DR InterPro; IPR044869; HNF-1_POU.
DR InterPro; IPR006898; HNF1a_C.
DR InterPro; IPR006897; HNF1b_C.
DR InterPro; IPR044866; HNF_P1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR11568; HEPATOCYTE NUCLEAR FACTOR 1; 1.
DR PANTHER; PTHR11568:SF4; HEPATOCYTE NUCLEAR FACTOR 1-ALPHA; 1.
DR Pfam; PF04814; HNF-1_N; 1.
DR Pfam; PF04813; HNF-1A_C; 1.
DR Pfam; PF04812; HNF-1B_C; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51937; HNF_P1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS51936; POU_4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..44
FT /note="HNF-p1"
FT /evidence="ECO:0000259|PROSITE:PS51937"
FT DOMAIN 78..173
FT /note="POU-specific atypical"
FT /evidence="ECO:0000259|PROSITE:PS51936"
FT DOMAIN 186..267
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 188..268
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 559 AA; 61531 MW; 0ED56EA24022DAF4 CRC64;
MEGEERKGEA GPGPGRLSAL QEQLIWALLG SGLSREVLVH ALGELERERV TPGAEKGDRG
DGESSEEGEM DFPPPIFQEL EALAPEEAAR QRALVDQLLQ EDPWRVAKLV KSYMQQHNLP
QREVVESIGL NQSHLSQHLN KGTPMKNQKR AALYSWYVRK QGEISQQFTN ARHALGSGEE
QGEDVRKGRR NRFKWGPASQ QILFHAYERQ RNPSKEEREG LVEECNRAEC LQRGVSPSQL
AGLGSNLVTE VRVYNWFANR RKEEAFRHKL ALDMPYNSQS ASSTNHTLSH SPEQGMKYSQ
QITCDNLGSS RGHNGDRGLG GRLASPIQLE PSHTLLETHH HKPVSGGGPL PPVSTLTSLH
SLSASPAPHH GLIMTSLPSV MSLGESSLLI GQTVPVINNV GGGFTTLQPI SFQQQLHSTS
QQQLTQQFQS HMGHHHSPFM ATMAQLPCHM YSKSDMSHYP PSSLLSQAMV ITDSSSLGTL
TSLTTVRQIL TTDPEEQTDQ PIQEDSLHLQ SPSPVPVSSG NLQLYPPSQS SESHPPHRLS
SSPADINSYI PAQMVSTAQ
//
