ID A0A1S2X521_SALSA Unreviewed; 445 AA.
AC A0A1S2X521;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000256|HAMAP-Rule:MF_03004, ECO:0000256|PIRNR:PIRNR016255};
DE Short=eIF3e {ECO:0000256|HAMAP-Rule:MF_03004};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000256|HAMAP-Rule:MF_03004};
GN Name=eif3ea {ECO:0000313|RefSeq:NP_001135167.1};
GN Synonyms=EIF3E {ECO:0000256|HAMAP-Rule:MF_03004}, eIF3e
GN {ECO:0000313|RefSeq:NP_001135167.1}, EIF3S6
GN {ECO:0000256|HAMAP-Rule:MF_03004}, eif3s6
GN {ECO:0000313|RefSeq:NP_001135167.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:NP_001135167.1};
RN [1] {ECO:0000313|RefSeq:NP_001135167.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19878547; DOI=10.1186/1471-2164-10-502;
RA Andreassen R., Lunner S., Hoyheim B.;
RT "Characterization of full-length sequenced cDNA inserts (FLIcs) from
RT Atlantic salmon (Salmo salar).";
RL BMC Genomics 10:502-502(2009).
RN [2] {ECO:0000313|RefSeq:NP_001135167.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (JUN-2017) to UniProtKB.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000256|HAMAP-Rule:MF_03004}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC EIF3M. {ECO:0000256|HAMAP-Rule:MF_03004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03004}.
CC Nucleus {ECO:0000256|HAMAP-Rule:MF_03004}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000256|HAMAP-
CC Rule:MF_03004, ECO:0000256|PIRNR:PIRNR016255}.
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DR RefSeq; NP_001135167.1; NM_001141695.1.
DR AlphaFoldDB; A0A1S2X521; -.
DR SMR; A0A1S2X521; -.
DR Ensembl; ENSSSAT00000072183; ENSSSAP00000045349; ENSSSAG00000046961.
DR GeneID; 100196666; -.
DR KEGG; sasa:100196666; -.
DR CTD; 325102; -.
DR OMA; TIQTNCP; -.
DR OrthoDB; 226348at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR Bgee; ENSSSAG00000046961; Expressed in pharyngeal gill and 15 other cell types or tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd21378; eIF3E; 1.
DR HAMAP; MF_03004; eIF3e; 1.
DR InterPro; IPR016650; eIF3e.
DR InterPro; IPR019010; eIF3e_N.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10317; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E; 1.
DR PANTHER; PTHR10317:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E; 1.
DR Pfam; PF09440; eIF3_N; 1.
DR Pfam; PF21357; EIF3E_C; 1.
DR Pfam; PF01399; PCI; 1.
DR PIRSF; PIRSF016255; eIF3e_su6; 1.
DR SMART; SM01186; eIF3_N; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03004};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW Rule:MF_03004}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03004};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW Rule:MF_03004}; Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 222..399
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
SQ SEQUENCE 445 AA; 52120 MW; 6DB87015FDE97E1B CRC64;
MAEYDLTTKI AHFLDRHLVF PLLEFLSVKE IYNEKELLHG KLDLLSETNM VDFAMDVHKN
LFPEKEIPAT LREKRITVVG QLKQLQGETE PIVKMFEDPE TTKQMQSTRD GQALFNYLAE
KHSFRQEYLD TLYRYAKFQY ECGNYSGAAE YLYFFRVLVP ATDRNALNSL WGKLASEILM
QNWEAAMEDL TRLRETIDNN SVSSPLQSLQ QRTWLIHWSL FVFFNHPKGR DNIIELFLYQ
PQYLNAIQTM CPHILRYLTT AVITNKDVRK RRQVLKDLVK VIQQESYTYK DPITEFVECL
YVNFDFDSAQ KKLRECESVL VNDFFLVACL EDFIENARLF IFETFCRIHQ CISISMLADK
LNMTPEEAER WIVNLIRNAR LDAKIDSKLG HVVMGNNAVS PYQQVIEKTK SLSFRSQMLA
MNIEKKMAHA SRNETPNWAG QETGF
//
