UniProt: A0A1S2XNM4

Database: UniProt
Entry: A0A1S2XNM4_CICAR

LinkDB:  A0A1S2XNM4_CICAR 
Original site:  A0A1S2XNM4_CICAR

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Ontology (3)   
   GO (3)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (6)   
   InterPro (3)   
   Pfam (1)   
   PROSITE (1)   
   SMART (1)   
All databases (12)   

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ID   A0A1S2XNM4_CICAR        Unreviewed;       335 AA.
AC   A0A1S2XNM4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Mitochondrial import inner membrane translocase subunit TIM50 {ECO:0000256|RuleBase:RU365079};
GN   Name=LOC101509691 {ECO:0000313|RefSeq:XP_004491501.1};
OS   Cicer arietinum (Chickpea) (Garbanzo).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX   NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004491501.1};
RN   [1] {ECO:0000313|RefSeq:XP_004491501.1}
RP   IDENTIFICATION.
RC   TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004491501.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the TIM23 complex, a complex that
CC       mediates the translocation of transit peptide-containing proteins
CC       across the mitochondrial inner membrane.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBUNIT: Component of the TIM23 complex.
CC       {ECO:0000256|RuleBase:RU365079}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC       inner membrane {ECO:0000256|ARBA:ARBA00004434,
CC       ECO:0000256|RuleBase:RU365079}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004434, ECO:0000256|RuleBase:RU365079}.
CC   -!- SIMILARITY: Belongs to the TIM50 family.
CC       {ECO:0000256|ARBA:ARBA00006344, ECO:0000256|RuleBase:RU365079}.
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DR   RefSeq; XP_004491501.1; XM_004491444.3.
DR   AlphaFoldDB; A0A1S2XNM4; -.
DR   STRING; 3827.A0A1S2XNM4; -.
DR   PaxDb; 3827-XP_004491501-1; -.
DR   GeneID; 101509691; -.
DR   KEGG; cam:101509691; -.
DR   eggNOG; KOG2832; Eukaryota.
DR   OrthoDB; 11362at2759; -.
DR   Proteomes; UP000087171; Chromosome Ca2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0005744; C:TIM23 mitochondrial import inner membrane translocase complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   CDD; cd07521; HAD_FCP1-like; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR004274; FCP1_dom.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   PANTHER; PTHR12210; DULLARD PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR12210:SF3; MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM50; 1.
DR   Pfam; PF03031; NIF; 1.
DR   SMART; SM00577; CPDc; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   PROSITE; PS50969; FCP1; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU365079};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW   ECO:0000256|RuleBase:RU365079};
KW   Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|RuleBase:RU365079};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW   Transit peptide {ECO:0000256|ARBA:ARBA00022946,
KW   ECO:0000256|RuleBase:RU365079};
KW   Translocation {ECO:0000256|ARBA:ARBA00023010,
KW   ECO:0000256|RuleBase:RU365079};
KW   Transmembrane {ECO:0000256|RuleBase:RU365079};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU365079};
KW   Transport {ECO:0000256|RuleBase:RU365079}.
FT   TRANSMEM        46..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365079"
FT   DOMAIN          147..291
FT                   /note="FCP1 homology"
FT                   /evidence="ECO:0000259|PROSITE:PS50969"
SQ   SEQUENCE   335 AA;  38452 MW;  5A1240A758BF9AC0 CRC64;
     MSLRILRSRL SSVASSSSNR FLCTNAAPAA PLPSPPSATS PNRWSFLKYA VIAAFTGTTV
     FTGYASYAYT VDEIDEKTKS FRESVKYTPS EGATALDKFQ GLLYSTAVTV PVKAVELYLD
     ARRLIEEQVR SYTEPYTDKL LPDLLPQEQH VFTLVVDLNE TLIHYIWTRE TGWQTFKRPG
     VDAFLEHLAQ FYEIVVYTDE QNMFVDPVIE RLDPKHCIRY RLSRPATKYQ DGKHYRDLSK
     LNRNPAKVLY LSGHAFESCL QPENCVPVKP WVQTDKDDTA LVDFIPFLEF VARSSPADIR
     PVLQSYQGCD IPSEFIRRSK EHQKRAQGQK RFWRN
//

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