ID A0A1S2Y4D9_CICAR Unreviewed; 466 AA.
AC A0A1S2Y4D9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN Name=LOC101494480 {ECO:0000313|RefSeq:XP_004499185.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004499185.1};
RN [1] {ECO:0000313|RefSeq:XP_004499185.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004499185.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
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DR RefSeq; XP_004499185.1; XM_004499128.3.
DR AlphaFoldDB; A0A1S2Y4D9; -.
DR STRING; 3827.A0A1S2Y4D9; -.
DR PaxDb; 3827-XP_004499185-1; -.
DR GeneID; 101494480; -.
DR KEGG; cam:101494480; -.
DR eggNOG; KOG4749; Eukaryota.
DR OrthoDB; 8233at2759; -.
DR Proteomes; UP000087171; Chromosome Ca4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.200.110; Inositol-pentakisphosphate 2-kinase, N-lobe; 1.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR InterPro; IPR043001; IP5_2-K_N_lobe.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF6; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 466 AA; 52141 MW; 83A0523AD8A03B95 CRC64;
MELTLTEQDA DNWVYRGEGA ANLVLSYNGS SFSYIGKVMR IRKSPRKESL LKGVRNSIAL
TPHERLIWKD VHELISSSDK EIAGQLYVQH VMKPLLGSKY VDAGNHILVT KEFLESVEKN
VVSQRPAWRV DVSRVDTQCD FGLLMSDHSL FPDGTETCIT ALDSTGCQGS SPSISVEIKP
KCGFLPQSEF ISEGTAIKRR VTRFEMHQAL KLQHGEVSQP SAYNPLDLFS GSKERIHKAI
KDLFATPQNN FRLFLNGSLI LGGLGGGAKT TDVCIAKVLE DELNSIIQAD DGLCTENLLT
LITEAVQKSG VLDQLLKVQK LDNVDIEGAI HAYYDITSQQ CRVCRELSEE QAKRYASLHS
ASLDESLRIV KDYLIAATAK DCSLMICFRP RKAEDSGAAY NTIYLESTKQ AFDFKVHFID
LDLKRMSKMD EYYELDKKIV SCYKQMSKMN RGRNEDANLQ GPEVAE
//
