ID A0A1S2Y5F8_CICAR Unreviewed; 798 AA.
AC A0A1S2Y5F8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC101494906 {ECO:0000313|RefSeq:XP_004499634.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004499634.1};
RN [1] {ECO:0000313|RefSeq:XP_004499634.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004499634.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000256|ARBA:ARBA00003861}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_004499634.1; XM_004499577.3.
DR AlphaFoldDB; A0A1S2Y5F8; -.
DR GeneID; 101494906; -.
DR OrthoDB; 1118232at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000087171; Chromosome Ca5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR CDD; cd01989; STK_N; 1.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR PANTHER; PTHR45647:SF15; U-BOX DOMAIN-CONTAINING PROTEIN 35; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 444..705
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 727..798
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REGION 239..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 363..421
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 471
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 798 AA; 89076 MW; BC5D89774039F557 CRC64;
MDRIQETDQS NKTRYSSSSA VALAIKGSKK SKYVVQWALN KFVPEGMIIF KLIHVHAVGV
VLPVSQVRND VAAAYKKEVE HQINQMVLPF KKMCEQRKVH VDVVLIESDD VASAVAEEVT
KDAITKLVIG ASSGGIFKSK QKSMSAKISV RTPRFCTVYA VSKGNLSIRP SDMQIDETIT
DDTSEISFSS SSSSNYTSTT QTDSGSVASY AALHTSSLAT QRFQALSNMN QTLLSTTHGL
NETNHSRGQS IDLGRENPAT SSARNSDFGR ALSRASSYRS IVSDPESWIN DQNCLKGSPV
ATKLSSPNRQ ENFTLELEKL RIELRHFQGM HAVAQTENID ASRKLNELSK RRSGESMKMK
EIIAKEEVAN ELATQQREKY EAAAREAEYL KECAEREAAE RKETELKAIR AAKEKEKLED
ALSGSTLQYR KFTWDEIVLA TSSFSEELKI GMGAYGMVYK CTLHHTTVAV KVLHSAGISQ
NKQFQQELEI LSRIRHPNLL LLLGACSDHG CLVYEYMENG NLEDRLLQKN SNNPIPWFER
FRIAWEVASA LSFLHSSKPQ PIIHRDLKPA NILLGRNLVS KIGDIGLSTI LNSDELSTMY
KDTAPVGTLS YIDPEYQRSG LISTKSDVYA FGLVMLQLLT AKPAIALTHV VEMAIEGGNL
TDILDPKAGS WPFQETLDLA RLALSCAELR RKDRPDLKDH VLPILERLKE VSDRAHHSAS
MITIKPKPPN HFICPILQDL MDDPCVAADG YTYNRNAIEK WLEENEKSPM TNMDLPHKLL
IPNYTLLSAI LEWKSKEI
//
