ID A0A1S2Y695_CICAR Unreviewed; 458 AA.
AC A0A1S2Y695;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN Name=LOC101494480 {ECO:0000313|RefSeq:XP_004499186.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004499186.1};
RN [1] {ECO:0000313|RefSeq:XP_004499186.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004499186.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
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DR RefSeq; XP_004499186.1; XM_004499129.3.
DR AlphaFoldDB; A0A1S2Y695; -.
DR GeneID; 101494480; -.
DR OrthoDB; 8233at2759; -.
DR Proteomes; UP000087171; Chromosome Ca4.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.200.110; Inositol-pentakisphosphate 2-kinase, N-lobe; 1.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR InterPro; IPR043001; IP5_2-K_N_lobe.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF6; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 458 AA; 51383 MW; E6A4BBC76A617BFF CRC64;
MELTLTEQDA DNWVYRGEGA ANLVLSYNGS SFSYIGKVMR IRKSPRKESL LKGVRNSIAL
TPHERLIWKD VHELISSSDK EIAGQLYVQH VMKPLLGSKY VDAGNHILVT KEFLESVEKN
VVSQRPAWRV DVSRVDTQCD FGLLMSDHSL FPDGTETCCQ GSSPSISVEI KPKCGFLPQS
EFISEGTAIK RRVTRFEMHQ ALKLQHGEVS QPSAYNPLDL FSGSKERIHK AIKDLFATPQ
NNFRLFLNGS LILGGLGGGA KTTDVCIAKV LEDELNSIIQ ADDGLCTENL LTLITEAVQK
SGVLDQLLKV QKLDNVDIEG AIHAYYDITS QQCRVCRELS EEQAKRYASL HSASLDESLR
IVKDYLIAAT AKDCSLMICF RPRKAEDSGA AYNTIYLEST KQAFDFKVHF IDLDLKRMSK
MDEYYELDKK IVSCYKQMSK MNRGRNEDAN LQGPEVAE
//
