ID A0A1S2Y882_CICAR Unreviewed; 450 AA.
AC A0A1S2Y882;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN Name=LOC101495995 {ECO:0000313|RefSeq:XP_004500990.1,
GN ECO:0000313|RefSeq:XP_012571462.1, ECO:0000313|RefSeq:XP_012571463.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004500990.1};
RN [1] {ECO:0000313|RefSeq:XP_004500990.1, ECO:0000313|RefSeq:XP_012571462.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004500990.1,
RC ECO:0000313|RefSeq:XP_012571462.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
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DR RefSeq; XP_004500990.1; XM_004500933.3.
DR RefSeq; XP_012571462.1; XM_012716008.2.
DR RefSeq; XP_012571463.1; XM_012716009.2.
DR STRING; 3827.A0A1S2Y882; -.
DR PaxDb; 3827-XP_004500990-1; -.
DR GeneID; 101495995; -.
DR KEGG; cam:101495995; -.
DR eggNOG; KOG4749; Eukaryota.
DR OrthoDB; 8233at2759; -.
DR Proteomes; UP000087171; Chromosome Ca5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.200.110; Inositol-pentakisphosphate 2-kinase, N-lobe; 1.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR InterPro; IPR043001; IP5_2-K_N_lobe.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF2; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 450 AA; 50537 MW; 95DC5DC85A24DE69 CRC64;
MEVILREKEA DDWIYRGEGA ANLVLAYNGS SSSFIGKVMR IRKAPRNDTP TVIASSPSAL
TAHERLLWKD VDELISSSDH EIASQLFVLH VMKPLLGSEY VDAGMHVQVS TGFLELVEKN
VICQRPAWRV DTAQVDMHCD YVLLMSDHSL FAHGNLGSSL CISVEIKPKC GFLPVSNFIS
EETSIKKSVT RFEMHQALKL HQGEISLLSE YNPLDLFSGS KEKIHKAIKD LFTTPQNNFR
VFMNGSLIFG GLGGGAEDTN FCIAKAFEVA LKSIIQSDDG LCTENFLTLV TEAAHKSGVL
DRLLEVQKLD NVDIEGAIHA YYDITHQQCM VCSELNEDQR KIYTPLHSAS LDESLTIVKD
YLIAATAKDC SLMICFRPSK EEESGSVCNN VYLESTKQTF DFKVYFIDLD LKRMSKMEEY
YELDKKIVSC YSEMLKMDQG RNEVPNLQES
//
