ID A0A1S2YHC0_CICAR Unreviewed; 551 AA.
AC A0A1S2YHC0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=GTP cyclohydrolase II {ECO:0000256|ARBA:ARBA00012762};
DE EC=3.5.4.25 {ECO:0000256|ARBA:ARBA00012762};
GN Name=LOC101504940 {ECO:0000313|RefSeq:XP_004504823.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004504823.1};
RN [1] {ECO:0000313|RefSeq:XP_004504823.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004504823.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-
CC pyrimidine + formate + 3 H(+) + 2 phosphate; Xref=Rhea:RHEA:23704,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58614; EC=3.5.4.25;
CC Evidence={ECO:0000256|ARBA:ARBA00029293};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-
CC ribitylamino)uracil from GTP: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004853}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the GTP
CC cyclohydrolase II family. {ECO:0000256|ARBA:ARBA00008976}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the DHBP synthase
CC family. {ECO:0000256|ARBA:ARBA00005520}.
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DR RefSeq; XP_004504823.1; XM_004504766.2.
DR AlphaFoldDB; A0A1S2YHC0; -.
DR STRING; 3827.A0A1S2YHC0; -.
DR PaxDb; 3827-XP_004504823-1; -.
DR GeneID; 101504940; -.
DR KEGG; cam:101504940; -.
DR eggNOG; KOG1284; Eukaryota.
DR OrthoDB; 5489599at2759; -.
DR UniPathway; UPA00275; UER00400.
DR Proteomes; UP000087171; Chromosome Ca6.
DR GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.90.870.10; DHBP synthase; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR HAMAP; MF_00179; RibA; 1.
DR HAMAP; MF_00180; RibB; 1.
DR HAMAP; MF_01283; RibBA; 1.
DR InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR InterPro; IPR000422; DHBP_synthase_RibB.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR InterPro; IPR016299; Riboflavin_synth_RibBA.
DR NCBIfam; TIGR00505; ribA; 1.
DR NCBIfam; TIGR00506; ribB; 1.
DR PANTHER; PTHR21327:SF37; GTP CYCLOHYDROLASE II; 1.
DR PANTHER; PTHR21327; GTP CYCLOHYDROLASE II-RELATED; 1.
DR Pfam; PF00926; DHBP_synthase; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
DR SUPFAM; SSF55821; YrdC/RibB; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619}.
FT DOMAIN 334..497
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
SQ SEQUENCE 551 AA; 59351 MW; 97A49CF6516CA281 CRC64;
MASSLNLSAP CLSRPRACRN FKLFHGLNSI NPSIVHVRGS DLAFVRLSSK FPSCLNAVSR
IKAALTSGGG DLKNEDLVGV ESVGTVAQPD AVVLETMGAD TALTGSGFAD DNDDFDSDSP
TKGFASIPEA IEDIKNGKMV VVVDDEDREN EGDLIMAAQL ATPEAMAFIV KHGTGIVCIS
MKEDDLERLE LPLMVNSKDN AEKLRTAFTV TVDAKHGTTT GVSAQDRATT VLALASKDSK
PSDFNRPGHI FPLKYTEGGV LKRAGHTEAS VDLAVLAGLD PVAVLCEVVD DDGSMARLPK
LRQFAERENL KVISIADLIR YRRKRDKLVE HAGAALIPTM WGPFTANCYR SLLDGMEHIA
MVKGDIGDGC DVLVRVHSEC LTGDIFGSAR CDCGSQLSLA MQQIEAAGRG VLVYLRGHEG
RGIGLGHKLR AYNLQDEGRD TVEANEELGL PVDSREYGIG AQILRDLRVH SMKLMTNNPA
KYVGLKGYGL SISGRIPLLS LITKENRRYL ETKRVKMGHM YGLEFNSKLN HIDGGNGNAS
SVDDSNVAPN T
//
