ID A0A1S2YSV7_CICAR Unreviewed; 1020 AA.
AC A0A1S2YSV7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Alpha-mannosidase {ECO:0000256|ARBA:ARBA00012752, ECO:0000256|RuleBase:RU361199};
DE EC=3.2.1.- {ECO:0000256|RuleBase:RU361199};
GN Name=LOC101497797 {ECO:0000313|RefSeq:XP_004509374.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_004509374.1};
RN [1] {ECO:0000313|RefSeq:XP_004509374.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_004509374.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU361199};
CC Note=Binds 1 zinc ion per subunit. {ECO:0000256|RuleBase:RU361199};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792, ECO:0000256|RuleBase:RU361199}.
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DR RefSeq; XP_004509374.1; XM_004509317.3.
DR AlphaFoldDB; A0A1S2YSV7; -.
DR STRING; 3827.A0A1S2YSV7; -.
DR PaxDb; 3827-XP_004509374-1; -.
DR GeneID; 101497797; -.
DR KEGG; cam:101497797; -.
DR eggNOG; KOG1959; Eukaryota.
DR OrthoDB; 5474711at2759; -.
DR Proteomes; UP000087171; Chromosome Ca7.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10810; GH38N_AMII_LAM_like; 1.
DR Gene3D; 2.60.40.1360; -; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 2.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR041147; GH38_C.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR048534; Man2a1-like_dom.
DR PANTHER; PTHR11607; ALPHA-MANNOSIDASE; 1.
DR PANTHER; PTHR11607:SF61; ALPHA-MANNOSIDASE; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF17677; Glyco_hydro38C2; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF21260; Laman-like_dom; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361199};
KW Hydrolase {ECO:0000256|RuleBase:RU361199};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361199};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW Signal {ECO:0000256|RuleBase:RU361199};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361199}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT CHAIN 30..1020
FT /note="Alpha-mannosidase"
FT /evidence="ECO:0000256|RuleBase:RU361199"
FT /id="PRO_5017844359"
FT DOMAIN 361..435
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
SQ SEQUENCE 1020 AA; 114244 MW; 1C959BDA94155172 CRC64;
MGNTRNLAAA ESLFVILFLF CICGTHVSAY TKYNTGAGVV EGKLNVHLVA HSHDDVGWLK
TVDQYYVGSN NIIQGACVEN VLDSVIWSLQ KDPNRKFIFG EMAFFHRWWV EQSPHTQEQV
RKLVDAGQLE FVNGGWSMHD EATCHYIDMI DQTTLGHRFI KKEFNTTPRA GWQIDPFGHS
SVQGYLLGAE LGFDSVHFAR IDYQDRAKRK DDKSLEVIWR GSKTFGSSAQ IFANTFPIHY
GAPTGFNFEL SNDIVPLQDD PLLFDTNVEQ RVNDFINASI TQANVTRTNH IMWTMGDDFS
YRFAETWFRQ MDKLIHYVNK DGRVNALYST PSLYTNAKNA ANQSWPLKTD DYFPYADGPN
AYWTGFFTSR PALKRYVRML SGYYLAARQL EFFAGNRSTI YNTFALGDAL GIAQHHDAVS
GTAQQHTTDD YAKRLAIGST KAEAVVSSSL ACLTGKKSGD HCSAPASAFS QCQLLNISYC
PPTEDNIPEA KDLVVVVYNS LGWNRTDIVR IPVNDANLVV KDSSGNNLEV QYVDVDNVTT
NLRNLYVKAY LGVSPKQAPK YWLLFQVSIP PLGWSTYFIS KGAGKSTRRK GVMSHLNSKT
GGNIDIGPGN LKMSFSSISG QLNRMYNTRT GVNIPIQQSY FWYASSNGGD DGFDSSDGQA
SGAYIFRPSK SSPNIVSRSV SFKVIRGPLV DEVRQKFSPW IYQVTRLYKG KEHAEIEFTV
GPIPSDDGVG KEVITRMTTN MVTNKEFYTD SNGRDFLKRV RDHREDWPLQ VNQPVAGNYY
PINLGIYTKD KKSELSVLVD RATGGSSIND GEVELMLHRR ILQDDGRGVE EPLDEDVCVT
ENSNCEGLTV RGNYYVSIDN VGAGSRWRRT TGQEIYSPLL LAFTHENAEN WKSSHLTKGT
VIDSNYSLPP NVALITLQEL EGGSVLLRLA HLYEPSEDAQ YSTLAKVELK KLFPTKTIKE
LKEVSLSANQ EKSEMKKMTW NVEGDKKGQE PQPVKGGPVS TSDFIVQLGP MEIRTFLLKF
//
