ID A0A1S2Z9H3_ERIEU Unreviewed; 391 AA.
AC A0A1S2Z9H3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Tumor susceptibility gene 101 protein {ECO:0000313|RefSeq:XP_007515929.1};
GN Name=TSG101 {ECO:0000313|RefSeq:XP_007515929.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007515929.1};
RN [1] {ECO:0000313|RefSeq:XP_007515929.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR RefSeq; XP_007515929.1; XM_007515867.1.
DR AlphaFoldDB; A0A1S2Z9H3; -.
DR STRING; 9365.ENSEEUP00000004489; -.
DR GeneID; 103107132; -.
DR CTD; 7251; -.
DR eggNOG; KOG2391; Eukaryota.
DR InParanoid; A0A1S2Z9H3; -.
DR OrthoDB; 37962at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF17; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SMART; SM00212; UBCc; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 323..391
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT REGION 195..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 240..312
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 200..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 44118 MW; E675D22D0D25059E CRC64;
MAVSENQLKK MVSKYKYRDL TVRETVNVIT LYKDLKPVLE SYVFNDGSSR ELMNLTGTIP
VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP
QSDLLGLIQV MIVVFGDEPP VFSRPTISAS YPPYQATGPP NTSYMPGMPS GISAYPSGYP
PNPSGYPGCP YPPGGPYPAT TSSQYPSQPP VTTVGPSRDG TISEDTIRAS LISAVSDKLR
WRMKEEMDRA QAELNALKRT EEDLKKGHQK LEEMVTRLDQ EVAEVDKNIE LLRKKDEELS
SALEKMENQS ENNDIDEVII PTAPLYKQIL NLYAEENAIE DTIFYLGEAL RRGVIDLDVF
LKHVRLLSRK QFQLRALMQK ARKTAGLSDL Y
//
