ID A0A1S2ZCY8_ERIEU Unreviewed; 961 AA.
AC A0A1S2ZCY8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Dynamin-like 120 kDa protein, mitochondrial {ECO:0000256|ARBA:ARBA00018307};
DE EC=3.6.5.5 {ECO:0000256|ARBA:ARBA00011980};
GN Name=OPA1 {ECO:0000313|RefSeq:XP_007517474.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007517474.1};
RN [1] {ECO:0000313|RefSeq:XP_007517474.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001837};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004434}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004434}. Mitochondrion membrane
CC {ECO:0000256|ARBA:ARBA00004325}.
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DR RefSeq; XP_007517474.1; XM_007517412.1.
DR AlphaFoldDB; A0A1S2ZCY8; -.
DR CTD; 4976; -.
DR OrthoDB; 48011at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR045817; OPA1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF67; DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF19434; OPA1_C; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 286..562
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT COILED 171..254
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 897..924
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 961 AA; 111649 MW; DCC1D9CED469C648 CRC64;
MWRLRRAAVA CEVCQSLVKH SSGVKGSIPL QKLHLVSRSI YHSHHPTIKL QRPQLRMSLQ
QFSSLTNLPL RKSKISPMKY GYQPRRNFWP ARLAARLLKL RYLILGSAVG GGYTAKKTFD
QWKDMIPDLS DYKWIVPDIV WEIDEYIDLG SSGETAFRAT EHGSENDKHY RKGLLGELIL
LQQQIQEHEE EARRAAGQYN TSYAQQKRKV SDKEKIDQLQ EELLHTQLKY QRILERLEKE
NKELRKIVLQ KDDKGIHHRK LKKSLIDMYS EVLDVLSDYD ASYNTQDHLP RVVVVGDQSA
GKTSVLEMIA QARIFPRGSG EMMTRSPVKV TLSEGPHHVA LFKDSSREFD LTKEEDLAAL
RHEIELRMRK NVKEGCTVSP ETISLNVKGP GLQRMVLVDL PGVINTVTAG MAPDTKETIF
SISKAYMQNP NAIILCIQDG SVDAERSIVT DLVSQMDPHG RRTIFVLTKV DLAEKNVASP
SRIQQIIEGK LFPMKALGYF AVVTGKGNSS ESIEAIREYE EEFFQNSKLL KTSMLKAHQV
TTRNLSLAVS DCFWKMVRES VEQQADSFKA TRFNLETEWK NNYPRLRELD RNELFEKAKN
EILDEVISLS QVTPKHWEEI LQQSLWERVS THVIENIYLP AAQTMNSGTF NTTVDIKLKQ
WTDKQLPNKA VEVAWETLQE EFSRFMTEPK GKEHDDIFDK LKEAVKEESI KRHKWNDFAE
DSLRVIQHNA LEDRSISDKQ QWDAAIYFME EALQARLKDT EDAIENMIGP DWKKRWLYWK
NRTQEQGIHN ETKNELEKML KCNEEHPAYL ASDEITTVRK NLESRGVEVD PSLIKDTWHQ
VYRRHFLKTA LNHCNLCRRG FYYYQRHFVD SELECNDVVL FWRIQRMLAI TANTLRQQLT
NTEVRRLEKN VKEVLEDFAE DSEKKVKLLT GKRVQLAEDL KKVREIQEKL DAFIEALHQE
K
//
