ID A0A1S2ZD10_ERIEU Unreviewed; 788 AA.
AC A0A1S2ZD10;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Disks large homolog 1 isoform X14 {ECO:0000313|RefSeq:XP_007517493.1};
GN Name=DLG1 {ECO:0000313|RefSeq:XP_007517493.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007517493.1};
RN [1] {ECO:0000313|RefSeq:XP_007517493.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007517493.1; XM_007517431.2.
DR AlphaFoldDB; A0A1S2ZD10; -.
DR GeneID; 103108491; -.
DR CTD; 1739; -.
DR OrthoDB; 2879721at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 3.
DR CDD; cd12031; SH3_DLG1; 1.
DR Gene3D; 2.30.42.10; -; 3.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR InterPro; IPR016313; DLG1-like.
DR InterPro; IPR019590; DLG1_PEST_dom.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF5; DISKS LARGE HOMOLOG 1; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF10608; MAGUK_N_PEST; 1.
DR Pfam; PF00595; PDZ; 3.
DR Pfam; PF10600; PDZ_assoc; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM01277; MAGUK_N_PEST; 1.
DR SMART; SM00228; PDZ; 3.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 3.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 108..195
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 203..290
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 350..431
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 465..535
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 598..773
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 16..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 546..560
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 788 AA; 87379 MW; ED4C8BE7D06CDD56 CRC64;
MNYIFGNNTL LYSRASRGGN TSSSHGSVGP KQKHWAKKGS SDELQAEPEP SRWQQIVAFF
TRRHSFIDCI SVATSSTQAN PPPVLVNTDS LETPTYVNGT DADFEYEEIT LERGNSGLGF
SIAGGTDNPH IGDDSSIFIT KIIAGGAAAQ DGRLRVNDCI LRVNEEDVRD VTHSKAVEAL
KEAGSIVRLY VKRRKPVSEK IMEIKLIKGP KGLGFSIAGG VGNQHIPGDN SIYVTKIIEG
GAAHKDGKLQ IGDKLLAVNS VCLEEVTHEE AVTALKNTSD FVYLKVAKPT SMYMNDGYAP
PDITNASSQH VDNHVSPSSY LGQTPASPAR YSPVSKAMLG DDEITREPRK VVLHRGSTGL
GFNIVGGEDG EGIFISFILA GGPADFSGEL RKGDRIISVN SVDLRTASHE QAATALKNAG
QAVTIVAQYR PEEYSRFEAK IHDLREQMMN SSISSGSGSL RTSQKRSLYV RALFDYDKTK
DSGLPSQGLN FKFGDILHVI NASDDEWWQA RQVTPDGESD EVGVIPSKRR VEKKERARLK
TVKFNSKTRD KGEIPDDMGS KGLKHVTSNA SDSESSYRGQ EEYVLSYEPV NQQEVNYTRP
VIILGPMKDR INDDLISEFP DKFGSCVPHT TRPKRDYEVD GRDYHFVTSR EQMEKDIQEH
KFIEAGQYNN HLYGTSVQSV REVAEKGKHC ILDVSGNAIK RLQIAQLYPI SIFIKPKSME
NIMEMNKRLA EDQARKTFER AMKLEQEFTE HFTAIVQGDT LEDIYNQVKQ IIEEQSGPYI
WVPAKEKL
//
