ID A0A1S2ZDT6_ERIEU Unreviewed; 784 AA.
AC A0A1S2ZDT6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cadherin-5 {ECO:0000256|ARBA:ARBA00021701};
DE AltName: Full=Vascular endothelial cadherin {ECO:0000256|ARBA:ARBA00030559};
GN Name=CDH5 {ECO:0000313|RefSeq:XP_007517858.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007517858.1};
RN [1] {ECO:0000313|RefSeq:XP_007517858.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_007517858.1; XM_007517796.2.
DR AlphaFoldDB; A0A1S2ZDT6; -.
DR STRING; 9365.ENSEEUP00000001414; -.
DR GeneID; 103108818; -.
DR CTD; 1003; -.
DR eggNOG; KOG3594; Eukaryota.
DR InParanoid; A0A1S2ZDT6; -.
DR OrthoDB; 3667774at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF89; CADHERIN-5; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..784
FT /note="Cadherin-5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010373344"
FT TRANSMEM 598..618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 78..147
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 148..254
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 255..369
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 370..476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 476..584
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 784 AA; 88153 MW; FA5A60A61C92056F CRC64;
MQMLVVLLIT AGTCLDLWAE AAADTDYAQL DLPRLPTHRR QKRDWIWNQM HIDEEKNTSL
PHYVGKIKSS VNRKNAQYVL KGEAADKVFK VNADTGDVYA FERLDREKIS EYHLTALVVD
KDTKKNLESP SSFTIKVHDI NDNWPVFTHR LFNASVPEMS NVGTSVIRVT AVDADDPTVA
DHASVMYQIL RGDKSFAIDN SGLIFTTTNN LDREMQAKYE VVVEARDAQG LRGESSTTTV
VISLQDVNDN FPIFTQTMYT FTVPEDIHVG SSVGSLFVKD PDEPQNRMTR YSIVYGEYKD
IFTIETDATH NEGIIKLRKP LDYERIQQYR FTAEATDPTI NLRLLGFIPN KNSASIIINV
TDVDEPPIFE KSAYYFKLRE NQKKPLVGSV KAIDPDAAQR SIGYSIRRTS DKGNFFQITK
KGDIYNDKEL DREVYPWYNL TIEAKELNLQ GFSTGKESIV QVYIEIEDEN DNAPIFAQPY
EPKVCENAAQ GKLVVQISAI DKDITPQDVK FKFSLSTENN NFTLTDNNDN TANITVKHGQ
FDREQAKVHF LPVLISDNGR PSLTSTSTLA VTVCKCDERG HFTFCEEAAG LAGVSVQALV
AIFLCILTIA VITLLIFLRR RLRRQAQANS KSVPEIHEQL VTYDEEGGGE MDTTSYDVSV
LNSVRCGGSV TKPPRAPREE LPPLYRQVQK PQLRPTGQQG SLGDMAAMIE MKKDEADQDD
GSPPYDTLHV YGYEGSESIA ESLSSLGTNS SGSDINYDFL NDWGPRFKML AELYGSDPQE
EMFY
//
