ID   A0A1S2ZDU4_ERIEU        Unreviewed;      1066 AA.
AC   A0A1S2ZDU4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Disheveled-associated activator of morphogenesis 2 isoform X5 {ECO:0000313|RefSeq:XP_007517865.1};
GN   Name=DAAM2 {ECO:0000313|RefSeq:XP_007517865.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007517865.1};
RN   [1] {ECO:0000313|RefSeq:XP_007517865.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007517865.1; XM_007517803.2.
DR   AlphaFoldDB; A0A1S2ZDU4; -.
DR   CTD; 23500; -.
DR   OrthoDB; 5485896at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR   Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR   Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014767; DAD_dom.
DR   InterPro; IPR015425; FH2_Formin.
DR   InterPro; IPR042201; FH2_Formin_sf.
DR   InterPro; IPR010472; FH3_dom.
DR   InterPro; IPR014768; GBD/FH3_dom.
DR   InterPro; IPR010473; GTPase-bd.
DR   PANTHER; PTHR45725:SF7; DISHEVELED-ASSOCIATED ACTIVATOR OF MORPHOGENESIS 2; 1.
DR   PANTHER; PTHR45725; FORMIN HOMOLOGY 2 FAMILY MEMBER; 1.
DR   Pfam; PF06367; Drf_FH3; 1.
DR   Pfam; PF06371; Drf_GBD; 1.
DR   Pfam; PF02181; FH2; 1.
DR   SMART; SM01139; Drf_FH3; 1.
DR   SMART; SM01140; Drf_GBD; 1.
DR   SMART; SM00498; FH2; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR   PROSITE; PS51231; DAD; 1.
DR   PROSITE; PS51444; FH2; 1.
DR   PROSITE; PS51232; GBD_FH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          40..416
FT                   /note="GBD/FH3"
FT                   /evidence="ECO:0000259|PROSITE:PS51232"
FT   DOMAIN          595..993
FT                   /note="FH2"
FT                   /evidence="ECO:0000259|PROSITE:PS51444"
FT   DOMAIN          1015..1046
FT                   /note="DAD"
FT                   /evidence="ECO:0000259|PROSITE:PS51231"
FT   REGION          515..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          434..510
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          688..715
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          964..1000
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        515..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..571
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1066 AA;  123014 MW;  7A118F306D81F6C4 CRC64;
     MAPHKRSRHG LGFLCCFGGT DLPEINLQDS HPLQYMEFSS PIPNPEELNI RFAELVDELD
     LTDKNREAVF ALPPEKKWQI YCSKKKEQED PNKLATSWPD YYIDRINSMA ALQSLYAFDE
     EETEMRNQVV EDLKTALRTQ PMRFVTRFIE LEGLTCLLNF LRSMDHATCE SRIHTSLIGC
     IKALMNNSQG RAHVLAQPEA ISTIAQSLRT ENSKTKVAVL EILGAVCLVP GGHKKVLQAM
     LHYQVYAAER TRFQTLLNEL DRSLGRYRDE VNLKTAIMSF INAVLNAGAG EDNLDFRLHL
     RYEFLMLGIQ PVIDKLRQHE NAILDKHLDF FEMVRNEDDL ELARRFDMVH IDTKSASQMF
     ELIHKKLKHT EAYPCLLSVL HHCLQMPYKR NGGYFQQWQL LDRILQQIVL QDERGMDPDL
     APLENFNVKN IINMLINENE VKQWREQAEK FRKEHMELVS RLEKKERECE TKTLEKEEMM
     RTLNKMKDKL ARESQELRQA RGQVAELVAQ LNEISTGPVS SPSPPGGPLF LSSSMTTSDL
     PPPPPPLPFA CCPPPPPPPL PPSGLPSPPG APPCFGLGLT LPSDPFPSND TPLRKKCVPQ
     PSHPLKSFNW VKLSEDRVPG TIWNEIDDMQ VFQILDLEDF EKMFSAYQRH QKELGSTEDI
     YLASRKVKEL SVIDGRRAQN CIILLSKLKL SNEEIRQAIL KMDEQEDLAK DMLEQLLKFI
     PEKSDIDLLE EHKHEIERMA RADRFLYEMS RIDHYQQRLQ ALFFKKKFQE RLAEAKPKVE
     AILLASQELI RSKRLMQMLE VVLAIGNFMN KGQRGGAYGF RVASLNKIAD TKSSTDRNIS
     LLHYLIMILE KHFPDILNLP SELQHLPEAA KVNLAELEKE VGNLRKGLRA VEVLEYQKHH
     MREPSDKFVP VMSDFITVSS FSFSELEDQL SEARDKFSRA LTHFGEHDSK MQPDEFFGIF
     DTFLQAFSEA RQDLETMRKR KEEEERRARM EAMLKEQRER ERWQRQRKVL AGSTLEEGGE
     FDDLVSALRS GEVFDKDLCK LKRSRKRSGG PALEVTRERA ISRLHY
//