ID   A0A1S2ZE84_ERIEU        Unreviewed;       802 AA.
AC   A0A1S2ZE84;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Ras GTPase-activating protein 4 isoform X2 {ECO:0000313|RefSeq:XP_007518053.1};
GN   Name=LOC103108989 {ECO:0000313|RefSeq:XP_007518053.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007518053.1};
RN   [1] {ECO:0000313|RefSeq:XP_007518053.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007518053.1; XM_007517991.2.
DR   AlphaFoldDB; A0A1S2ZE84; -.
DR   CTD; 100271927; -.
DR   eggNOG; KOG2059; Eukaryota.
DR   InParanoid; A0A1S2ZE84; -.
DR   OrthoDB; 24454at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0071277; P:cellular response to calcium ion; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:InterPro.
DR   CDD; cd04054; C2A_Rasal1_RasA4; 1.
DR   CDD; cd13372; PH_CAPRI; 1.
DR   CDD; cd05395; RasGAP_RASA4; 1.
DR   Gene3D; 2.60.40.150; C2 domain; 2.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR039360; Ras_GTPase.
DR   InterPro; IPR037777; RASA4_PH.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR001562; Znf_Btk_motif.
DR   PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR   PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR   Pfam; PF00779; BTK; 1.
DR   Pfam; PF00168; C2; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   PRINTS; PR00360; C2DOMAIN.
DR   SMART; SM00107; BTK; 1.
DR   SMART; SM00239; C2; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50004; C2; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR   PROSITE; PS51113; ZF_BTK; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00432}.
FT   DOMAIN          1..105
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          116..232
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
FT   DOMAIN          306..516
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   DOMAIN          570..677
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          782..802
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   802 AA;  89880 MW;  D9A61E859E43FF5B CRC64;
     MAKRSSLSIR IVEGKNLPAK DITGSSDPYC IVKVDNEPII RTATVWKTLS PFWGEEYQVH
     LLPTFHTVAF YVLDEDALSR DDVIGKVCLS RDTLASHPKG FCGWAHLTEV DPDEEVQGEI
     HLRLEVLPGP PAPRLRCSVL EARDLAPKDR NGTSDPFVRV RYNGRTQETS IVKKSCYPRW
     NETFEFELEE GVSGALCVEA WDWDLVSRND FLGKVVFNVP RLGAAPLEEG WFRLQPDQAK
     HQQPEAAHPR GNLGSLQLEV RLRDETVLPS YCYQPLVRLL CQEVTLGTQG PGQLIPLIEE
     LTSTECRQDV ATNLLKLFLG QGLAKDFLDL LFQLELARTS EANTLFRSNS LASKSMESFL
     KVAGMRYLHG VLGPIIDRVF EDKKYVELDP SKVEVKDVGC SGLHRPTTEA EVLEQSAHTL
     RGHLGALLSA LSRSVRACPA VVRATFRQLF LRVRERFPSA QHENVPFIAV TSFLCLRFFS
     PAIMAPKLFH LRERHADART SRTLLLLAKA VQNVGNMDTL ASRAKEAWME PLQPTVRQGV
     AQLKDFITKL VDIGEKEELD LQRTLSLQAP PVKEGPLFIH RTKGKGPLMS SSFKKLHFSL
     TTEALSCAKT PSSKKSALIK LASVRAAEKV EEKSFGSSHV MQVIYSDDVG RPQTAYLQCK
     CVNELNQWLS ALRKVIMNNP SLLGSYHPGV FRGDKWSCCH QRDRTDLGCD KTRSRVTLQE
     WNDPLDHDLE AQLLYRHLQG LEAELWQRHR SQNVGTETDP GEASRDALAQ LLQVLGNLRE
     AHGSSHTGPL PVEPTRLLAL QT
//