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Database: UniProt
Entry: A0A1S2ZEM0_ERIEU
LinkDB: A0A1S2ZEM0_ERIEU
Original site: A0A1S2ZEM0_ERIEU 
ID   A0A1S2ZEM0_ERIEU        Unreviewed;      1048 AA.
AC   A0A1S2ZEM0;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   SubName: Full=integrin alpha-5 {ECO:0000313|RefSeq:XP_007518203.1};
GN   Name=ITGA5 {ECO:0000313|RefSeq:XP_007518203.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007518203.1};
RN   [1] {ECO:0000313|RefSeq:XP_007518203.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit.
CC       {ECO:0000256|SAAS:SAAS01130326}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003762};
CC       Single-pass type I membrane protein
CC       {ECO:0000256|RuleBase:RU003762}.
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC       {ECO:0000256|RuleBase:RU003762, ECO:0000256|SAAS:SAAS00534092}.
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DR   RefSeq; XP_007518203.1; XM_007518141.1.
DR   STRING; 9365.XP_007518203.1; -.
DR   GeneID; 103109131; -.
DR   CTD; 3678; -.
DR   OrthoDB; 743479at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.130; -; 1.
DR   InterPro; IPR013517; FG-GAP.
DR   InterPro; IPR013519; Int_alpha_beta-p.
DR   InterPro; IPR000413; Integrin_alpha.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   Pfam; PF01839; FG-GAP; 2.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PRINTS; PR01185; INTEGRINA.
DR   SMART; SM00191; Int_alpha; 5.
DR   SUPFAM; SSF69179; SSF69179; 3.
DR   PROSITE; PS51470; FG_GAP; 7.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE   3: Inferred from homology;
KW   Cell adhesion {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Integrin {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414648, ECO:0000313|RefSeq:XP_007518203.1};
KW   Membrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414656};
KW   Receptor {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS01101220};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Repeat {ECO:0000256|SAAS:SAAS00048613};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00494686};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU003762,
KW   ECO:0000256|SAAS:SAAS00414628}.
FT   SIGNAL        1     38       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        39   1048       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010182431.
FT   TRANSMEM    998   1020       Helical. {ECO:0000256|RuleBase:RU003762}.
FT   REPEAT       40    105       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      125    185       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      190    242       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      256    308       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      309    374       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      375    434       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   REPEAT      438    501       FG-GAP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00803}.
FT   DOMAIN      487    920       Integrin_alpha2. {ECO:0000259|Pfam:
FT                                PF08441}.
SQ   SEQUENCE   1048 AA;  114081 MW;  E64FBA07DB4907BC CRC64;
     MGSWTPGSPL PAAPRRRPPR PPPLLSLLLL LLPPGAGGFN LDAEAPAVFS GPPGSFFGFS
     VEFYRPGTDG VSVLVGAPKA NTSQPGVLQG GAVYLCPGGT GTAPCTQLEF DRKGPRYLDV
     SLSSQEEEEP LEYKSLQWFG ATVRAHGSSV LACAPLYSWR TEKDPQSDPV GTCYLATKDF
     THYLEYAPCR SDFSSAAGQG YCQGGFSAEF TKTGRVVLGG PGSYFWQGQI LSATQEQIIK
     SYYYDYLISP VEGQLQTRQA SSIYDDSYLG YSVAVGEFSG DDVEDFVAGV PKGNLTYGYV
     TILSGSDIRS LYNFSGEQMA SYFGYAVAAT DVSGDGLDDL LVGAPLLMER TADGRPQEVG
     RVYVYLQHPA GMEPTPTITL TGSDEFGRFG SSLTPLGDLD QDGYNDVAIG APFGGETQQG
     VVFIFPGGPR GLGSKPSQVL LPLWAAGHSP DFFGSALRGG RDLDGNGYPD LIVGSFGVDK
     AVVYRGRPIV SASASLTIFP AMFNPEERSC SLEGNPVACI NLSFCLNASG KHVPDSIGFT
     VELQLDWQKQ KGGVRRALFL ASKQATLIQP LLIQNGARED CREMKIYLRN ESEFRDKLSP
     IHVALNFSLD PQAPVDSHGL RPVLHYQSKS RIEDKAQILL DCGEDNICVP DLQLEVFGEQ
     NRVFLGDKNA LNLTFHAQNV GEGGAYEAEL RVTAPPEAEY SGLVRNPGNF SSLSCEYSAV
     NQSRLLVCDL GNPMKAGASI WGGLRFTVPH LRDTKETIQF DFQILSKNIN NSQSDLVSFQ
     LSVEAQAQVS LNGVSKPEKV TFPVSDWHPP DQPQEEGDVG PAVHHVYELI NMGPSSISQG
     VLEVRCPYAL QNQSLLYVTR ITGLSNCTTS HPPNPQSLKL DPEVPQNHLL QKREAPGRST
     ASSGTQVLKC SEHNCFKLHC ELGPLHRMEI RSLQLHFRVW AKTFLQLEHQ SFDLKCEAVY
     QALKMPYLIL PRELPQKELE VATNVHWINA EGSQGVPLWI IILAILFGLL LLGLLIYILY
     KLGFFKRSLP YGTAMEKAQL KPPATSDA
//
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