ID   A0A1S2ZF10_ERIEU        Unreviewed;       532 AA.
AC   A0A1S2ZF10;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Keratin, type II cytoskeletal 4 {ECO:0000313|RefSeq:XP_007518373.1};
GN   Name=KRT4 {ECO:0000313|RefSeq:XP_007518373.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007518373.1};
RN   [1] {ECO:0000313|RefSeq:XP_007518373.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; XP_007518373.1; XM_007518311.1.
DR   AlphaFoldDB; A0A1S2ZF10; -.
DR   STRING; 9365.ENSEEUP00000005449; -.
DR   GeneID; 103109268; -.
DR   CTD; 3851; -.
DR   eggNOG; ENOG502QQIF; Eukaryota.
DR   InParanoid; A0A1S2ZF10; -.
DR   OrthoDB; 4640531at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF3; KERATIN, TYPE II CYTOSKELETAL 4; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          149..462
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          153..287
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          353..440
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   532 AA;  56738 MW;  DDAA258C1FD8C027 CRC64;
     MISRQQGVRS GSRGFSVGSA IVGGGKKSAF SSASVAGGAG RCSSGGFGSR SLYNLGGNKS
     ISMSMAGFRQ GAGLGAAGGF GAAGGFGAGG FGAGFGTGGG LGGAFNGRGG PGFPVCPAGG
     IQEVTINQSL LTPLHVEIDP EIQKVRTEER EQIKTLNNKF ASFIDKVRFL EQQNKVLETK
     WNLLQQQTTT TSSKNLDPFF ETYISVLRKQ LDSLVNDKGR LQSELKLMQD SVEDFKTKYE
     DEINKRTAAE NDFVVLKKDV DAAYMTKVEL EAKVDGLNDE VNFLRALYAA ELAQMQTHVS
     DTSVVLSMDN NRCLDLDSII AEVRAQYEEI AQKSKLEAES LYQTKVQQLQ TSVDQHGDSL
     KNTKSEIAEL NRMIQRLRAE IENVKKQCQT LQASVADAEQ RGELALKDAY SKRTELEAAL
     QKAKEELARL LRDYQALMNV KMALDVEIAT YRKLLEGEEC RMSGECQSSV SISVVGGSIS
     TGGLGGGYGS SSGLCLGGGF GSGSGSGFGY GGGVHSSSSG KMISTSSTLK RY
//