ID A0A1S2ZGU8_ERIEU Unreviewed; 407 AA.
AC A0A1S2ZGU8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Homeobox protein aristaless-like 4 {ECO:0000313|RefSeq:XP_007519167.1};
GN Name=ALX4 {ECO:0000313|RefSeq:XP_007519167.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007519167.1};
RN [1] {ECO:0000313|RefSeq:XP_007519167.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_007519167.1; XM_007519105.1.
DR AlphaFoldDB; A0A1S2ZGU8; -.
DR GeneID; 103109961; -.
DR CTD; 60529; -.
DR eggNOG; KOG0490; Eukaryota.
DR InParanoid; A0A1S2ZGU8; -.
DR OrthoDB; 5400675at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR PANTHER; PTHR24329:SF322; HOMEOBOX PROTEIN ARISTALESS-LIKE 4; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 206..266
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 387..400
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 208..267
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 56..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..109
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 43062 MW; 2B9B87E7B6598308 CRC64;
MNAETCVSFC ESPAAAMDAY YSPVSQSREG SSPFRAYPGG DKFGAAFLAG TTAAKGQGFG
DAKGRARYGA EQQDLAAPLD GGPGARGSFG KFPPPPPAPQ PPAPQPAPQP ASQAHLYLQR
GACKTPPAGG LKLSEGSGGH NAALQVPCYA KESSLGEPEL PPDSDTVGMD SSYLSVKEAG
VKGPQDRASA DLPSPLEKAD SESNKGKKRR NRTTFTSYQL EELEKVFQKT HYPDVYAREQ
LAMRTDLTEA RVQVWFQNRR AKWRKRERFG QMQQVRTHFS AAYELPLLTR AENYAQIQNP
SWIGNNGAAS PVPACVVPCD PVPTCMSPHT HPPGSGASGV TDFLGVSGAS SHVGQTHMGG
LFGAAGLSPG LNGYELNGSG EPDRKTSSIA ALRMKAKEHS AAISWAT
//
