ID A0A1S2ZIK3_ERIEU Unreviewed; 642 AA.
AC A0A1S2ZIK3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN Name=NDC80 {ECO:0000313|RefSeq:XP_007519922.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007519922.1};
RN [1] {ECO:0000313|RefSeq:XP_007519922.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR RefSeq; XP_007519922.1; XM_007519860.2.
DR AlphaFoldDB; A0A1S2ZIK3; -.
DR STRING; 9365.ENSEEUP00000010537; -.
DR GeneID; 103110696; -.
DR CTD; 10403; -.
DR eggNOG; KOG0995; Eukaryota.
DR InParanoid; A0A1S2ZIK3; -.
DR OrthoDB; 25325at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 213..285
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 321..400
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 458..538
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 73924 MW; 5FF4F04D191B057E CRC64;
MKRSSASTGG AGRLSMQELR SQELPRQGLY TPQTKEKPAF GKLSINKPTS ERKVSVFGKR
TSGHGSRNSQ FGIFSNSEKI KDPRPLSDKT FIQQCIRQLC EFLTENGYAY SVSMKSLQAP
SVKDFLKIFS FLYGFLCPSY ELPATKFEEE IPRIFKNLGY PFALSKSSMY TVGAPHTWPH
IVAALVWLID CIKLHNAMKD RPPLFDDGQS WGEETEDGIM HNKLFLDYTI KCYESFMTGA
DSFEDMNAEL QLKLKDLFNV DASKLESLAA ENKALNEQIT RREREREKEP NRLESLRKTK
LALQADIQNY QAFKSNLESH SAILDQKLNG LDEEISRIEA ECEALQQENS RLQNVVDTQK
YSVADIERIN HERNELQQTI NKLTRDLEAE QQQLWNEELK YAKGKEAIDM QLAEYHKLAR
KLKLIPKGSE NSKGHDFEIK FHPETGTNCL VKYRAQVYVP LKELLNQTEE EINKAQNKKM
GLEDTLEQLN TMITDSKRSV RTLKEEVQKL EDLHQQKLKE AEEEDQKCAS ELESLEKHKR
LLENVVNEGL SEARDELDTV QREYQLVVQI TTEERRKVGN NLQRLLEMVA THVGSVEKHL
QEQIAKTDRE YEECGSEDLL ESVKETGDKY EKRAALFKTA DE
//
