ID A0A1S2ZIQ3_ERIEU Unreviewed; 780 AA.
AC A0A1S2ZIQ3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Protein Jade-2 isoform X3 {ECO:0000313|RefSeq:XP_007519966.2};
GN Name=JADE2 {ECO:0000313|RefSeq:XP_007519966.2};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007519966.2};
RN [1] {ECO:0000313|RefSeq:XP_007519966.2}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007519966.2; XM_007519904.2.
DR AlphaFoldDB; A0A1S2ZIQ3; -.
DR STRING; 9365.ENSEEUP00000013486; -.
DR CTD; 23338; -.
DR eggNOG; KOG0954; Eukaryota.
DR OrthoDB; 163389at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15705; ePHD_JADE2; 1.
DR CDD; cd15680; PHD_JADE2; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039549; JADE2_ePHD.
DR InterPro; IPR039548; JADE2_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793:SF84; E3 UBIQUITIN-PROTEIN LIGASE JADE-2; 1.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 195..245
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 247..361
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 574..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..670
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 755..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 86898 MW; 1F566C9AF47B0567 CRC64;
MEEKRRKYSI SSDNSDTTDS HATLASRCSK LPSSTKSGWP RQNEKKPSEV FRTDLITAMK
IPDSYQLSPD DYYILADPWR QEWEKGVQVP AGAEAIPEPV VRILPPLEGP QVSPSFSELG
EGSQPDWPGG SRYDLDEIDA YWLELINSEL KEMERPELDE LTLERVLEEL ETLCHQNMAR
AIETQEGLGI EYDEDVVCDV CRSPEGEDGN EMVFCDKCNV CVHQACYGIL KVPTGSWLCR
TCALGVQPKC LLCPKRGGAL KPTRSGTKWV HVSCALWIPE VSIGCPEKME PITKISHIPA
SRWALSCSLC KECTGTCIQC SMPSCVTAFH VTCAFDHGLE MRTILADNDE VKFKSFCQEH
SDGGPQTEPT SEPMEPSPAG EDLEKVTLRK QRLQQLEEDF YELVEPAEVA ERLDLAEALV
DFIYQYWKLK RKANANQPLL TPKTDEVDNL AQQEQDVLYR RLKLFTHLRQ DLERVRNLCY
MVTRRERTKH ALCKLQEQIF HLQMKLTEQD LCRGLSTSFP IDGTFFNSWL AQSVQITAEN
MAMSEWSLNN GHREDPAPGL LSEELLQDEE TLLSFMRDPS LRPGDPARKA RGRTRLPAKK
KSPQDGPAAR TTPDKTPKKT WGQEAGSGKG GQGPAARKPP RRAPYLPSPV TRDCPIPSAP
KSPPPLAPET LDEVTPVDAD SDVQVPGPTP SPKPSGRLRP PRESKGTRRW SGARPDSGTG
PPSAVAERPK VSLHFDTETD GYFSDGEMSD SDVEAEESGV QRGPREAGAE EVVRMGVLAS
//
