ID A0A1S2ZJV1_ERIEU Unreviewed; 1408 AA.
AC A0A1S2ZJV1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Telomerase-binding protein EST1A {ECO:0000256|RuleBase:RU369098};
DE EC=3.1.-.- {ECO:0000256|RuleBase:RU369098};
GN Name=SMG6 {ECO:0000313|RefSeq:XP_007520455.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007520455.1};
RN [1] {ECO:0000313|RefSeq:XP_007520455.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex
CC that is essential for the replication of chromosome termini.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- FUNCTION: Plays a role in nonsense-mediated mRNA decay.
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU369098};
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|RuleBase:RU369098}. Chromosome, telomere
CC {ECO:0000256|RuleBase:RU369098}. Cytoplasm, cytosol
CC {ECO:0000256|RuleBase:RU369098}.
CC -!- DOMAIN: The PINc domain confers endonuclease activity and is expected
CC to bind the catalytic metal ion. {ECO:0000256|RuleBase:RU369098}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007520455.1; XM_007520393.2.
DR STRING; 9365.ENSEEUP00000003215; -.
DR GeneID; 103111141; -.
DR CTD; 23293; -.
DR eggNOG; KOG2162; Eukaryota.
DR InParanoid; A0A1S2ZJV1; -.
DR OrthoDB; 3094546at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW.
DR CDD; cd09885; PIN_Smg6-like; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR018834; DNA/RNA-bd_Est1-type.
DR InterPro; IPR019458; Est1-like_N.
DR InterPro; IPR045153; Est1/Ebs1-like.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR15696; SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7; 1.
DR PANTHER; PTHR15696:SF40; TELOMERASE-BINDING PROTEIN EST1A; 1.
DR Pfam; PF10374; EST1; 1.
DR Pfam; PF10373; EST1_DNA_bind; 1.
DR Pfam; PF13638; PIN_4; 1.
DR SMART; SM00670; PINc; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|RuleBase:RU369098};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU369098};
KW Endonuclease {ECO:0000256|RuleBase:RU369098};
KW Hydrolase {ECO:0000256|RuleBase:RU369098};
KW Manganese {ECO:0000256|RuleBase:RU369098};
KW Metal-binding {ECO:0000256|RuleBase:RU369098};
KW Nonsense-mediated mRNA decay {ECO:0000256|ARBA:ARBA00023161,
KW ECO:0000256|RuleBase:RU369098}; Nuclease {ECO:0000256|RuleBase:RU369098};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU369098};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Telomere {ECO:0000256|RuleBase:RU369098}.
FT DOMAIN 1235..1386
FT /note="PIN"
FT /evidence="ECO:0000259|SMART:SM00670"
FT REGION 21..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 850..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..334
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1408 AA; 159507 MW; B5673A626DC444B9 CRC64;
MAEGLERVRI SASELRGILA TLAPQAGSRE NMKEPRQRKD NRRPDLEIYK PGLSRLRNKV
KIKEPSGIDE YKDEIVNDRD SSVGNGVQLI KDVCKELDNQ NCPADPENVR VQESFPRTAG
QEDKSLRIIK RAKKPDMQIY QPGRRLHTLS KELTNQADEE EIINQVEQLR VEDECRGNGK
EEAVNKPDRE VADKSPCGDR VRVPKGERGK RVEKGEGMKK MNDDAAQGKP GSAKRYSRSD
KRRNRYRTCS TSSAGSNNSA EGTGLTDNGC RRRRQDRTKD RPRLKKQVSM SSTDSLDEDR
IDEVDGPRSS ERKKHLERNC SGRGEGEQKS NGKENRGNLR VTFDAETMSK DSPAVRSTRE
DMDRLKSDKS SSSGGKGSEK QGSKNLKQEL QGRGRGILIL PAHTTLSVNS ASSPESTPLG
PRLLFGSGSK GSRSWGRGGT TRRLWDPNNP DQKPALKSQT PQLHFLDTDD EVSPTSWGDS
RQAQASYYKF QNSDNPYYYP RTPGPASQYP YPGYSPLQYP VGPTNGVYPG PYYPGYPTPS
GQYVCSPLPA STMSPEELEQ HMRNMQQQEL HRLLRVADNQ ELQLSNLLSR DRISPEGLEK
MAQLRAELLQ LYERCILLDI EFSDNQNVDQ ILWKNAFYQV IEKFRQLLKD PNVENPEQIR
NRLLELLDEG SDFFDSLLQK LQVTYKFKLE DYMDGLAIRS KPLRKTVKYA LISAQRCMIC
QGDIARYREQ ANDTANYGKA RSWYLKAQHI APKNGRPYNQ LALLAVYTRR KLDAVYYYMR
SLAASNPILT AKESLMSLFE ETKRKAEQME KKQQEESELS SDQWRKGKKS TFQHVGEDTT
RLEIWIHPSH SRSCQGTESG KDSEQENGLG SLSPNDLNKR FILSFLHAHG KLFTRIGMET
FPAVAEKVLK EFQVLLQHSP SPIGSTRMLQ LMTINMFAVH NSQLKDCFSE ECRSVIQEQA
AALGLAMFSL LVRRCTYLLK ESAKAQLSSP EDEDDQDDIK VSSFVPDLKE LLPSVKVWSD
WMLGYPDTWN PPPTSLDLPS QVAVDVWSML ADFCNILTAV NQSEVPLYKD PDDDLTLLIL
EEDRLLSGFV PLLAAPQDPC YVEKTSDKVI AADCKRVTVL KYFLEALCGQ EEPLLAFKGG
KYVSVAPVPD TMGKEMGSQE GKQLEDEEED VVIEDFEEDS EAEGSVAEDD IRELRAKKLA
LARKIAEQQR RQEKIQAVLE DQSQMRQMEL EIRPLFLVPD TNGFIDHLAS LARLLESRKY
ILVVPLIVIN ELDGLAKGQE TDHRAGGYAR VVQEKARKSI EFLERRFESR DSCLRALTSR
GNELESIAFR SEDITGQLGN NDDLILSCCL HYCKDKAKDF MPTNKEEPIR LLREVVLLTD
DRNLRVKALT RNVPVRDIPA FLTWAQVG
//
