ID A0A1S2ZLH7_ERIEU Unreviewed; 609 AA.
AC A0A1S2ZLH7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Basic helix-loop-helix ARNT-like protein 1 {ECO:0000256|ARBA:ARBA00041169};
DE AltName: Full=Aryl hydrocarbon receptor nuclear translocator-like protein 1 {ECO:0000256|ARBA:ARBA00042144};
DE AltName: Full=Brain and muscle ARNT-like 1 {ECO:0000256|ARBA:ARBA00041751};
GN Name=ARNTL {ECO:0000313|RefSeq:XP_007521211.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007521211.1};
RN [1] {ECO:0000313|RefSeq:XP_007521211.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus, PML body {ECO:0000256|ARBA:ARBA00004322}.
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DR RefSeq; XP_007521211.1; XM_007521149.2.
DR AlphaFoldDB; A0A1S2ZLH7; -.
DR CTD; 406; -.
DR eggNOG; KOG3561; Eukaryota.
DR InParanoid; A0A1S2ZLH7; -.
DR OrthoDB; 2872674at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd11438; bHLH-PAS_ARNTL_PASD3; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23042:SF52; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR23042; CIRCADIAN PROTEIN CLOCK/ARNT/BMAL/PAS; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Receptor {ECO:0000313|RefSeq:XP_007521211.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 72..125
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 143..208
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 346..395
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 609 AA; 67167 MW; CF1EA9AB40416149 CRC64;
MADQRMDISS TISDFMSPGA TDLLSSPLGT SGVDCNRKRK GSTTDYQESM DTNKDGPHGR
LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP TCNAMSRKLD KLTVLRMAVQ
HMKTLRGAAS PYTEANYKPT FLSDDELKHL ILRAADGFLF VVGCDRGKIL FVSESVFKIL
NYNQNDLIGQ SLFDYLHPKD IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC
SGARRSFFCR MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED
NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV FVDQRATAIL
AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT NCYKFKIKDG SFITLRSRWF
SFMNPWTKEV EYIVSTNTVV LTNALEGGDP AFPQVTASPH SMDSILLSGE GGPKRTHPTV
PGIPGGTRAG AGKIGRMIAE EIMEIHRQVA PSGCSVSRCF SAQDAVFPEG VSVTSGGFWP
SRHVGIVTDP SLSCPTGENP HIGTDMIDND QGSSSPSNDE AAMAVIMSLL EADAGLGGPV
DFSDLPWPL
//
