ID   A0A1S2ZME7_ERIEU        Unreviewed;       495 AA.
AC   A0A1S2ZME7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 {ECO:0000313|RefSeq:XP_007521612.1};
GN   Name=ENTPD2 {ECO:0000313|RefSeq:XP_007521612.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007521612.1};
RN   [1] {ECO:0000313|RefSeq:XP_007521612.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   RefSeq; XP_007521612.1; XM_007521550.2.
DR   AlphaFoldDB; A0A1S2ZME7; -.
DR   STRING; 9365.ENSEEUP00000008519; -.
DR   GeneID; 103112159; -.
DR   CTD; 954; -.
DR   eggNOG; KOG1386; Eukaryota.
DR   InParanoid; A0A1S2ZME7; -.
DR   OrthoDB; 180318at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        461..484
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         204..208
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   495 AA;  54535 MW;  A140706F9CBE5A0F CRC64;
     MAGKLLSLLP LVLLTALGLA GLLLLCISTR HVQEPPALKY GIVLDAGSSH TSMFIYKWPA
     DKENDTGIVN QHSFCDVHGG GISSYADDPP GAGQSLTECL DQALQDVPKE SHATTPLYLG
     ATAGMRLLHL TSPETSDKVL RAVKSKLTQY PFDFRGVHIL SGQEEGVFGW VTANYLLENF
     IKYNWAGLWF RPRKGTLGAM DLGGASTQIT FETDRPAEDP TTEVQLRLYG QAYHVYTHSF
     LCYGRDQVLL RLQAAVLQTG GSHPCWPRGY STQVQLQDMY RSPCTAAQQP QTFNGSTRIS
     MWGRSDTVQC RNLVSGLFNF SSCQFSQCSF DGVFQPPVAG NFIAFSAFFY TVDFMRTTMG
     LPVGTLRQLE AAVKTLCNQT WDELQLRAPG KQAHLPHYCA MAMFVQQLLS QGYGFNERTF
     SDVTFQRKAG DTTVGWALGY MLNLTNMIPA DPPGLRRGLA LSSWVVLLLL FATIMLVSLV
     LLLCQARSTK SSSVI
//