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Database: UniProt
Entry: A0A1S2ZMS1_ERIEU
LinkDB: A0A1S2ZMS1_ERIEU
Original site: A0A1S2ZMS1_ERIEU 
ID   A0A1S2ZMS1_ERIEU        Unreviewed;      4660 AA.
AC   A0A1S2ZMS1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 10.
DE   SubName: Full=LOW QUALITY PROTEIN: ryanodine receptor 3 {ECO:0000313|RefSeq:XP_007521775.1};
GN   Name=RYR3 {ECO:0000313|RefSeq:XP_007521775.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Insectivora; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007521775.1};
RN   [1] {ECO:0000313|RefSeq:XP_007521775.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_007521775.1; XM_007521713.1.
DR   GeneID; 103112313; -.
DR   CTD; 6263; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_007521775.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3974   3997       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4201   4221       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4266   4288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4461   4482       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4541   4564       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      111    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    218       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      226    280       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      286    344       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      354    411       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      596    807       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1078   1290       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3709   3744       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      470    490       {ECO:0000256|SAM:Coils}.
FT   COILED     3043   3063       {ECO:0000256|SAM:Coils}.
FT   COILED     3223   3243       {ECO:0000256|SAM:Coils}.
FT   COILED     3902   3922       {ECO:0000256|SAM:Coils}.
FT   COILED     4123   4143       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4660 AA;  528519 MW;  5D8140522BE20AD5 CRC64;
     MSLATSTSQC KDCQTNQFCS LLRDFCNWED EVVLQCIANV HKEQRKFCLA AEGLGNRLCF
     LEPTSEAKFV PPDLCVCNFV LEQSLSVRAL QEMLANTVEN GGEGAAQGGG HRTLLYGHAI
     LLRHSFSGMY LTCLTTSRSQ TDKLAFDVGL REQATGEACW WTIHPASKQR SEGEKVRIGD
     DLILVSVSSE RYLHLSVSNG NIQVDASFMQ TLWNVHPTCS GSSVEEGYLL GGHVVRLFHG
     HDECLTIPST DQNDSQHRRI FYEAGGAGTR ARSLWRVEPL RISWSGSNIR WGQAFRLRHL
     TTGHYLALTE DQGLILQDRG KSDTKSTAFC FRASKEIKEK LDSSHKRDIE GMGVPEIKYG
     DSVCFVQHIA SGLWVTYKAQ DAKTSRLGPL KRKVILHQEG HMDDGLTLQR CQCEESQAAR
     IIRNTTALFS QFISGNNRTT APMALPIEEV LQTLQDLIAY FQPPEEEMRH EDKQNKLRSL
     KNRQNLFKEE GMLALVLNCI DRLNIYNSVA HFAGLAREES GMAWKEVLSL LYKLLAALIR
     GNRSNCAQFS NNLDWLISKL DRLESSSGIL EVLHCILTES PEALNLIAEG HIKSIISLLD
     KHGRNHKVLD VLCSLCLCNG VAVRANQNLI CDNLLPRRNL LLQTRLINDV TSIRPNIFLG
     VAEGSAQYRK WYFELIIDQV EPFLTAEPTH LRVGWASSSG YAPYPGGGEG WGGNGVGDDL
     YSYGFDGLHL WSGRIPRAVA SINQHLLKSD DVVSCCLDLG VPSISFRING QPVQGMFENF
     NTDGLFFPVV SFSAGVKVRF LMGGRHGEFK FLPPSGYAPC YEALLPKEKM RLEPVKEYKR
     DADGVRDLLG TTQFLSQASF IPCPIDTSQV VLPPHLEKIR DRLAENIHEL WGMNKIELGW
     TFGKVRDDNK RQHPCLVEFS KLPETEKNYN LQMSTETLKX VFNLKIIYKT DGQRWHQGSG
     YFGRTWHPGD VVGCMINLDD ASMIFTLNGE LLITNKGSEL AFADYEIENG FVPICSLGLS
     QVGRMNLGMD ASTFKFYTMC GLQEGFEPFA VNMNRDVAMW FSKRLPTFIN VPRNHPHIEV
     LRIDGTMDSP PCLKVTHKTF GTQNSSASMI YCRLSMPVEC HSSFSHSPCL DSDAFQKKKQ
     LQEILSHTTT QCYYAIRIFA GQDPSCVWVG WVTPDYHLYS EKFDLSKNCT VTVTLGDERG
     RVHESVKRSN CYMVWGGDIV ATSQRSSRSN VDLEIGCLVD LAMGMLSFSA NGRELGTCYQ
     VEPNTKVFPA VFLQPTSTSL FQFELGKLKN AMPLSAAIFK SEEKNPVPQC PPRLDVQTIQ
     PVLWSRMPNS FLKVETERVS ERHGWVVQCQ EPLQMMALHI PEENRCVDIL ELCEQEDLLQ
     FHFHTLRLYS AVCALGNSRV AFALCSHVDL SQLFYTIDNK YLPGLLRAGF YDLLISIHLA
     NSKERKLMMK NEYIIPITST TGKIHLYPDK SKRHGLPGVG LRTCLKPGFK FSTPCFVLTG
     EEHQRQSPEI PLEILKTKAL GMLTEAVHCS GPHIRDPVGG SVEFQFVPVL KLIGTLLVMG
     VFDDDDVRQI LLLIDPSVFG DHSGETEEGA GKEEVTQEEE KAVEAGEKAN KEAPVKGLLQ
     TRLPESVKLQ MCELLSYLCD CELQHRVEAI VAFGDIYVSK LQANQKFRYN ELMQALNMSA
     ALTARKTREF RSPPQEQINM LLNFQLGENC PCPDEIRGEL YDFHEDLLIH CGVPLEEEEE
     VVEDTSWTGK LRTLVYKIKG PPRPEKEQPT EEEEKRCPTT LKELISQTMI HWAQEDQIQD
     AELIRMMFNL LRRQYDSIGE LLQALRKTYT ISQASVRDTI HLLAALGQIR CLLSVRMGKE
     EELLMINGLG DIMNNKVFYQ HPNLMRVLGM HETVMEVMVN VLGAEKSQIA FPKMVASCCR
     FLCYFCRISR QNQKAMFEHL SYLLENSSVG LASPSMRGST PLDVAASSVM DNNELALGLE
     EPDLEKVVTY LAGCGLQSCA MLLAKGYPDV GWNPIEGERY LSFLRFAVFV NSESVEENAS
     VVVKLLIRRP ECFGPALRGE GGNGLLAAMQ GAIKISENPA LDLPSQGYKR EVKDNGEEEE
     EIVHMGNAIM SFYSALIDLL GRCAPEMHLI QTGKGEAIRI RSILRSLVPT EDLVGIISIP
     LKLPSLNKDG SVSEPDMAAN FCPDHKAPMV LFLDRVYGIK DQTFLLHLLE VGFLPDLRAS
     ASLDTVSLSI TEAALALNRY LCSAVLPLLT RCAPLFAGTE HYTSLIDSTL QTIYRLFKGR
     SLTKAQRDTI EECLLAICNH LRPSMLQQLL RRLVFDVPQL NEYCKMPLKL LMNHYEQCWK
     YYCLPSGWGS YGLAVEEELH LTEKLFWGIF DSLSHKKYDP DLFRMALPCL SAIAGALPPD
     YLDTRISTTL EKQVSVDADG NFDPKPINTM NFSLPEKLEF IVTKYAEHSH DKWACDKSQN
     GWKYGISLDE NVRTHPLIRP FKTLTEKEKE IYRWPARESL KTMLAMGWTV ERTKEGEALV
     QQRENEKLRS VSQASQGNSY SPAPLDLSNV VLSRELQGMV EVVAENYHNI WAKKKKLELE
     SKGGGSHPLL VPYDTLTAKE KFRDREKAQD LFKFLQVNGI MVSRGTKDLE LDASSMEKRF
     AYKFLKKILK YVDSAQEFIA HLEAIVSSGK TERSPHDQEI KFFAKVLLPL VDQYFTNHRL
     YFLSSPLKPL SSSGYASHKE KEMVASLFCK LAALVRHRIS LFGSDSTTMV SCLHILAQTL
     DTRTVMKSGS ELMKAGLRAF FENAAEDLEK TSENLKLGKF THSRTQIKGV SQNINYTTVA
     LLPILTSIFE HVAQHQFGVD LLLGDVQISC YHILCSLYSL GTGKNIYVER QRPALGECLA
     SLTAAIPVAF LEPGLNCYNP LSVFNTKTSR ERSILGMPDT VEEMCPDVPQ LEGLMKEINT
     LAESGARYTE MPHVIEVILP MLCNYLSYWW EQGPEHLPPN TGPWCTKVTS EHLSVILGNI
     LKIINNNLGI DEASWMKRIA VYAQPIISKA RPDLLKSHFI PTLEKLKKKA VKTVQEEEQL
     KADNKGDTQE AELLILDEFA VLCRDLYAFY PMLIRYVDNN RSNWLKSPDA DSDQLFRMVA
     EVFILWCKSH NFKREEQNFV IQNEINNLAF LTGDSKSKMS KAMQVKSGGQ DQERKKTKRR
     GDLYSIQTSL IVAALKKMLP IGLNMCTPGD QELISLAKAR YSYRDTDEEV KEHLRNNLHL
     QEKSDDPAVK WQLNLYKDVL KSEEPSSPEK TVERVQRISA AVFHLEQVEQ PLRSKKAVWH
     KLLSKQRKRA VVACFRMAPL YNLPRHRSIN LFLHGYQRFW IETEEYSFEE KLVQDLAKSP
     KVEEEEEEEE MEKQPDPLHQ IILHFSRNAL TERSKLEDDP LYTSYSSMMA KSCQGGEEEE
     DEEDKEKTFE EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV IETLKLGIAI
     LNGGNAGVQQ KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT
     LIVRERGEKV LQNDEFTRDL FRFLQLLCEG HNSDFQNFLR TQMGNTTTVN VIISTVDYLL
     RLQESISDFY WYYSGKDIID ESGQHNFSKA LAVTKQIFNS LTEYIQDSSQ IELLKELLDL
     LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE
     YDPDSKGIIS KKEFQKAMEG QKQYTQSEID FLLSCAEADE NDMFNYIDFV DQFHEPAKDI
     GFNVAVLLTN LSEHMPNDSR LKCLLGPAES VLNYFEPYLG RIEIMGGAKK IERVYFEISE
     SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS QISETDLADR
     PEEEEEDEVS SYTLDIEGEE EDNTSFEPIS AFAMACISIK RNVTHFLKKA TLKNLRKQYR
     KVKKMSVREL VKEFFSFFWM LFVGLFQLFF TILGGIFQIL WSTVFGGGLV EGAKNIRVTK
     ILGDMPDPTQ FGIHDDAMEV ERAEVTEPGI TTELVHFVKG QKGDAEIMSD LFGFHSKKEG
     GLKHGPEVGL GDLSEIIGKD EPPTLESTVQ KKRKAQAAEM KAAHETEGKV ESEKADMEDG
     EKENCAKEEK QAAALWAEAV KKKKRRRGQK VEKPEALMAN FFKGLEIYQT KLLHYLARNF
     YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN SFNDEDEEEA MVFFVLQEST
     GYMAPALRAL AIIHTVISLV CVVGYYCLKV PLVVFKREKE IARKLEFDGL YITEQPSEDD
     IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN KYGDLYGAER IAELLGLDKN ALDFSPVEET
     KAEAASLVSW LSSIDMKYHV WKLGVVFTDN SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA
     MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD
     DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD ITFFFFVIVI LLAIIQGLII
     DAFGELRDQQ EQVREDMETK CFICGIGNDY FDTTPHGFET HTLQEHNLAN YLFFLMYLIN
     KDETEHTGQE SYVWKMYQER CWDFFPAGDC FRKQYEDQLG
//
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