ID A0A1S2ZMS2_ERIEU Unreviewed; 339 AA.
AC A0A1S2ZMS2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Paired box protein Pax-9 {ECO:0000256|ARBA:ARBA00016206};
GN Name=PAX9 {ECO:0000313|RefSeq:XP_007521778.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007521778.1};
RN [1] {ECO:0000313|RefSeq:XP_007521778.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transcription factor required for normal development of
CC thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal
CC elements of skull and larynx as well as distal limbs.
CC {ECO:0000256|ARBA:ARBA00002731}.
CC -!- SUBUNIT: Interacts with KDM5B. {ECO:0000256|ARBA:ARBA00011734}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_007521778.1; XM_007521716.1.
DR AlphaFoldDB; A0A1S2ZMS2; -.
DR STRING; 9365.ENSEEUP00000006746; -.
DR CTD; 5083; -.
DR eggNOG; KOG3517; Eukaryota.
DR InParanoid; A0A1S2ZMS2; -.
DR OrthoDB; 5393942at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00131; PAX; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR043182; PAIRED_DNA-bd_dom.
DR InterPro; IPR001523; Paired_dom.
DR InterPro; IPR043565; PAX_fam.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45636; PAIRED BOX PROTEIN PAX-6-RELATED-RELATED; 1.
DR PANTHER; PTHR45636:SF13; PAIRED BOX PROTEIN PAX-9; 1.
DR Pfam; PF00292; PAX; 1.
DR PRINTS; PR00027; PAIREDBOX.
DR SMART; SM00351; PAX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00034; PAIRED_1; 1.
DR PROSITE; PS51057; PAIRED_2; 1.
PE 4: Predicted;
KW Paired box {ECO:0000256|ARBA:ARBA00022724};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..130
FT /note="Paired"
FT /evidence="ECO:0000259|PROSITE:PS51057"
SQ SEQUENCE 339 AA; 36242 MW; 47031D6FE69012B5 CRC64;
MEPAFGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH GCVSKILARY
NETGSILPGA IGGSKPRVTT PTVVKHIRTY KQRDPGIFAW EIRDRLLADG VCDKYNVPSV
SSISRILRNK IGNLAQQSHY DSYKQHQPAP QPALPYNHIY SYPSPISAAT AKGPTPPGVP
ALPGSVAMPR TWPSSHSVTD ILGIRSITDQ VSDSSSYHSP KVEEWSSLGR NNFSATAPHA
VNGLEKGALE QEAKYGQAPN GLPAVSSFVS ASSMAPYPTQ VSPYMTYSAS PSGYVAGHGW
QHASGTPLSP HNCDIPTSLA FKGMQAAREG SHSVTASAL
//
