ID   A0A1S2ZNQ4_ERIEU        Unreviewed;       893 AA.
AC   A0A1S2ZNQ4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Pre-mRNA-splicing factor CWC22 homolog {ECO:0000256|ARBA:ARBA00040488};
DE   AltName: Full=Nucampholin homolog {ECO:0000256|ARBA:ARBA00042174};
GN   Name=CWC22 {ECO:0000313|RefSeq:XP_007522216.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007522216.1};
RN   [1] {ECO:0000313|RefSeq:XP_007522216.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC   -!- SIMILARITY: Belongs to the CWC22 family.
CC       {ECO:0000256|ARBA:ARBA00006856}.
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DR   RefSeq; XP_007522216.1; XM_007522154.2.
DR   AlphaFoldDB; A0A1S2ZNQ4; -.
DR   STRING; 9365.ENSEEUP00000004896; -.
DR   GeneID; 103112681; -.
DR   CTD; 57703; -.
DR   eggNOG; KOG2140; Eukaryota.
DR   InParanoid; A0A1S2ZNQ4; -.
DR   OrthoDB; 1115942at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   Gene3D; 1.25.40.180; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   PANTHER; PTHR18034; CELL CYCLE CONTROL PROTEIN CWF22-RELATED; 1.
DR   PANTHER; PTHR18034:SF3; PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG; 1.
DR   Pfam; PF02847; MA3; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51366; MI; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          446..562
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          646..893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..116
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..429
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        654..703
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        725..772
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        785..835
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        845..893
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   893 AA;  103765 MW;  83AC701EAE1F914E CRC64;
     MKSSVGQIKH SSGHDRKENY NSHQKVSSPE DRSAEQERSP RDRDYYDYSR SDYERSRRGC
     SYDSSMESRS RDREKHRERD VNRKRSRRTP SPVRRSPEHA QDEPSTKKKK DELDPLLTRT
     GGAYIPPAKL RMMQEQITDK NSLAYQRMSW EALKKSINGL INKVNISNIG IIIQELLQEN
     IVRGRGLLSR SVLQAQSASP IFTHVYAALV AIINSKFPQT GELILKRLIL NFRKGYRRND
     KQLCLTASKF VAHLINQNVA HEVLCLEMLT LLLERPTDDS VEVAIGFLKE CGLKLTQVSP
     RGINAIFERL RNILHESEID KRVQYMIEVM FAVRKDGFKD HPVILGGLDL VEEDDQFTHM
     LPLEDEYNPE DVLNVFKMDP NFMENEEKYK EIKKEILDEG DSDSNTDQDA GSSEDEDEEE
     EEEEGEEDEE GQKVTIHDKT EINLVSFRRT IYLAIQSSLD FEECAHKLLK MEFPESQTKE
     LCNMILDCCA QQRTYEKFFG LLAGRFCMLK KEYMESFESI FKEQYDTIHR LETNKLRNVA
     KMFAHLLYTD SLPWSVLECI RLSEETTTSS SRIFVKIFFQ ELCEYMGLPK LNARLKDETL
     QPFFEGLLPR DNPRNTRFAI NFFTSIGLGG LTDELREHLK NTPKVIVAQK PDIEPDKSSS
     SSSSSASSSS ESDSSASDSD SSDSSSESSS EESDSSSSSS QSSSSDKDRR KKRQGKTKNK
     VDKLTRKQHK NDKKQEERRP EQRYQETRTE RERRSEKHRD KNSRDTKWRD SITKYSSEQN
     NYSGVVKDRD QEMHPDLENK HGGPKKKRSE RRNSFSENEH RHRNKDSENY KRRERSKSRE
     KTRRHSGSRS GEDSYQNGAE RRCDKSSRCF ELSRESRKSH DRGREKSPTK QKK
//