ID A0A1S2ZQ61_ERIEU Unreviewed; 4483 AA.
AC A0A1S2ZQ61;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Dynein heavy chain 9, axonemal {ECO:0000313|RefSeq:XP_007522835.1};
GN Name=DNAH9 {ECO:0000313|RefSeq:XP_007522835.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007522835.1};
RN [1] {ECO:0000313|RefSeq:XP_007522835.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_007522835.1; XM_007522773.2.
DR STRING; 9365.ENSEEUP00000006050; -.
DR GeneID; 103113246; -.
DR CTD; 1770; -.
DR eggNOG; KOG3595; Eukaryota.
DR InParanoid; A0A1S2ZQ61; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1862..1998
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2140..2271
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2467..2618
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3080..3142
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3286..3334
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4483 AA; 512938 MW; 0EA1CC044C33CEBE CRC64;
MLSLEERMAR AQQNAEEEPA ADPRLRLLGA YVARSLRPAA GAWERCTGTA EAEHLLRDFL
GRSSAEEGPR PLLLVQPGPG GLAVRAGLDA GLPRAKGLFF LRTSPEPPGP RSLRGAVLCG
DLPAAPLQHL AALFAEVIIP VLTNEKNHLD WPHVLCQDIR RHVHHLQCEF LVILEQVKGK
TLLPLPVGSE KMQFVDSESE AILDSTDKSV IYAIESAVIQ WSHRVQVVLK RESSQPLIKG
ENPTPKVELE FWKSRSEDLE YIYNQLRTIK VRGMTELLDK LQSSYFPAFQ AMFRDIVAAL
KEAQDIHTHL MPLHRHLETI EGMEFPEVKP RLRPLLHVVC LIWATCSPYR CPGRLTVLLQ
EICNLLILQA SNYLSPEDLL RSEVEESQRK LHVVVDTLSF FKQVFQDRRE KLHTYFKESH
EVKNWDFQSS LVFVRLDDFL GRLHMVEDLL NTTLDFQKLE KLEFSGIRGN ALSQQVQQMY
DEFQEMYRVF SESSYDCLEP QSREFENDLF EFNQRVEDLD RRLGTIFIQA LEDAPDLEHA
FKLLDIAGNL LERPLVAVDV SDKLWILIQM FNRDLDMVRT IYSQRIQQEA ELGFSTVHKN
MPTVAGGLRW AQELRQRIQK PFSNFQRLTH PCMESAEGKR MIQKYEDTMS LLEIYEKRLY
ENWCQTVSEK SQYNLSQSLL KRDRETKQIT VNFNPQLISV LKEMSYLEPR PMEHIPETAA
TMFSSRKFYR QLVAHLELMA NWYNKVMKTL LEVEFPLVEE QLRNIDLCLK AAEETLNWKS
EGIWDYVIKT ANSIHNFEQR IQKTKDNVEE IKTIMKTWVS PIFKRKDGKK ECLLAMDDQH
DRVEKHYSLI KESGSKIHAL VQENLHLFLA DPTSNSWKTY VKYIDDMLLD GFFLAIECSL
KYLLENTEYK AGLTPVFEAQ LNLTVPELVF CPSLESGVKG GFYDIVESLV IKIFRISSLV
PRVSPWNGSP HYQADMEGTS DLTNMRNRLM ERVQNMMSLC CSYRNTFNQY SYLYVEDRKE
ILSQFLLYGH VLTPEEIEAQ AEDAIPESPP LLHQFKAQID SYEKLYEEVS RLEPIKVFDN
WMKIDVRPFK ATLLNIIKRW SLMFKQHLVD YVTNSLADLD LCIRNSESGL LKKVEKGDFK
GLVEIVGHLV ALKDRQGSTD EMFEPLKQTI ELLRNYEQEL PETVFLLLEE LPEKWNKLKK
MAVTVRQQVA PLQANEVTLL RQRCTAFEVE QQQFLEQFHK EAPFRFDSTD PHQMLDVRHM
EILEMESTMA SISESASLFE VSVPDYKHLK QCRKEVCQLK ELWDTIGMVT SSIRAWESTK
WKDINVEAMD LECKRFTRHI RNLDKEVRTW DAFTGLESTV VNTLTSLRAV AELQNPAIRE
RHWRQLMQAT GVSFAMDEGT TLAHLLQLQL HHFEDEVRGI VDKAVKEMGM EKTLKELQTT
WAGMQFQYEC HPRTRVLLLQ CDDDLIEVLE DNQVQLQNLM MSKYIAFFLE EVSGWQKKLS
TADAVIAIWF DVQRTWSHLE SIFIGSEDIR AQLPQDSKRF EGIDIDFKEL AYDAQKTPNV
VEATNKSGLY EKLEDIQSRL YLCEKALAEY LDTKRLAFPR FYFLSSSDLL DILSNGTVPQ
QVQRHLSKLF DNMAKMQFQE DSSEKPSKTS LGMYSKEDEY VAFSEPCDCS GQVEVWLNHV
LAHMKATVRH EMTEGVTAYE EKPREQWLFD YPAQVALTCT QIWWTTEVGI AFARLEEGYE
TAMKEYYKKQ VGQLKTLITM LIGQLSKGDR QKIMTICTID VHARDVVAKM IAQKVDNAQA
FLWLSQLRHR WDDEAKHCFA NICDAQFLYS YEYLGNTPRL VITPLTDRCY ITLTQSLHLT
MSGAPAGPAG TGKTETTKDL GRALGIMVYV FNCSEQMDYK SCGNIYKGLA QTGAWGCFDE
FNRISVEVLS VVAVQVKSIQ DAIRDKKQQF NFLGEEISLN PSVGIFITMN PGYAGRTELP
ENLKALFRPC AMVVPDFELI CEIMLVAEGF IEARLLARKF ITLYQLCKEL LSKQDHYDWG
LRAIKSVLVV AGSLKRGDPD RPEDQVLMRS LRDFNIPKIV TDDMPVFMGL IGDLFPALDV
PRRRDLNFEA LVRKAIVDLK LQAEDNFVLK VVQLEELLAV RHSVFVVGSA GTGKSQVLRS
LHKTYQIMKL RPVWTDLNPK AVTNDELFGI INPATREWKD GLFSSIMREL TNITHDGPKW
ILLDGDIDPM WIESLNTVMD DNKVLTLASN ERIPLNPTMR LLFEISHLRT ATPATVSRAG
ILYINPADLG WNPPVSSWID KREIQTERAN LTILFDKYLP TCLDTLRTRF KKIIPIPEQS
MVQMLCHLLE CLLTKEDIPP DCPKEIYELY FVFAAIWAFG GAMVQDQLVD YRAEFSKWWL
TEFKTVKFPS QGTIFDYYID PETKKFELWS KLIPQFEFDP EMPLQACLVH TSETIRICYL
MERLMERQHP VMLVGTAGTG KSVLVGSKLA SLDAEEYTVK NVPFNYYTTS AMLQAVLEKP
LEKKAGRNYG PAGNKKLIYF IDDMNMPEVD AFGTVQPHTI IRQYLDYGHW YDRNKLTLKE
IMNVQYVSCM NPTAGSFTIN PRLQRHFSVF VLPFPGADSL ASIYSTILTH HLKLGNFPAS
LQKSIPPLIN LALTFHQKIA NTFLPTAIKF HYVFNLRDFA NIFQGILFSS VECVKSTQDL
VKLYLHESNR VYRDKMVEEK DFDLFDKIQT EVVKKNFDDI GEMVGQTGSL NMYCHFANGV
GESKYMPVQS WEVLTQTLME ALDNHNEVNT VMDLVLFEDA MCHVCHISRI LESPRGNALL
VGVGGSGKQS LTRLAAFISS MDVFQITLRK GYQIPDFKAD LASLCFKAGV KNVSTVFLMT
DAQVADEKFL VLINDLLASG EIPDLYSDDE VENIISNVKN EVKNQGLVDT RENCWKFFID
RVRRQLKVAL CFSPVGNKLS IRSRKFPAIV NCTAIDWFHE WPQQALESVS FRFLQSMECI
EPTVRQSISK FMAFVHTSVN QTSQSYLSNE QRYNYTTPKS FLEFIRLYQN LLVRNGQELK
SKMERLENGL LKLHGTSAQV DDLKTKLATQ EVELKQKNED ADKLIQVVGV ETDKVSREKA
IADEEEQKVA LIMLEVKQKQ KDCEEDLAKA EPALTAAQAA LNTLNKTNLT ELKSFGSPPL
AVSNVSAAVM VLMAPGGKVP KDRSWKAAKV TMAKVDGFLD SLIHFDKENI HENCLKAIRP
YLQDPEFNPD FVATKSYAAA GLCSWVINIV RFYEVFCDVE PKRQALSKAT SDLTTAQEKL
EAIKTKIAHL NDNLAKLTAK FEKATADKLK CQQEAEVTSG TISLANRLVG GLTSENVRWA
EAVQNLKQQE SKLCGDVLLV TAFISYLGFF TKKYRQSLMD ATWIPYLSQL KVPIPITPTL
DPLRMLTDDA DVAAWQNEGL PADRMSMENA TILINCERWP LMVDPQLQGI KWIKNKYGED
LRVTQIGQKG YLQTIEHALE AGEVVLIENL EESIDPVLGP LLGREVIKKG RFIKIGDKEC
EYNPKFRLIL HTKLASPHYQ PELQAQATLI NFTVTRDGLE DQLLAAVVSM ERPDLERLKS
DLTKQQNGFK ITLKTLEDNL LSRLSSASGN FLGETALVEN LEITKQTAAE IEKKVQEAKV
TEVKINEARE HYRPAAARAS VLYFIMNDLS KIHPMYQFSL KAFSIVFQKA VEKAIPSESL
SERVTNLIDS ITFSVYQYTT RGLFECDKLT YLAQLTFQIL LMNQEVGAAE LDFLLRSPVQ
TGVTSPVDFL SHQAWGGIKA LSSMEEFFNL DRDIEGSAKS WKKFVESECP EKEKFPQEWK
NKTALQRLCM MRAMRPDRMA YAMRDFVEEK LGSRYVLGRA LDFAASFEES GPSTPMFFIL
SPGVDPLKDV ENQGKKLGYT FNNQNFHNVS LGQGQEVVAE ATLELAAQKG HWVILQNIHL
VAKWLSTLEK KLEEHSNNSH PEFRVFISAE PAPSPEGHII PQGILENSIK ITNEPPMGMH
ANLHKALDNF TQDTLEMCSR ETEFKSILFA LCYFHAVVAE RRKFGPQGWN RVYPFNTGDL
TISVNVLYNF LEANTKVPYD DLRYLFGEIM YGGHITDDWD RRLCRTYLEE FVKPEMLEGE
LCLAPGFPLP GNMDYNGYHQ YIDAKLPPES PYLYGLHPNA EIGFLTQTSE KLFRTVLELQ
PRDSHTGNGA GATREEKVKT LLEEILERVT DEFNIPELMA KVEERTPYIV VALQECERMN
ILTREIQRSL KELDLGLKGE LTMTSDMENL QNALYLDTVP ESWARRAYPS TAGLATWFLD
LLNRIKELEA WVGDFAMPST VWLTGFFNPQ SFLTAIMQSM ARKNEWPLDQ MALQCDVTKK
NREELRSPPR EGAYVHGLFI EGAGWDAQAG IITEAKLKDL TPPMPVIFIK AIPADKQDCR
SVYLCPVYKT CQRGPTYVWT FNLKTKENPS KWVLAGVALL LQT
//
