ID A0A1S2ZR32_ERIEU Unreviewed; 628 AA.
AC A0A1S2ZR32;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Netrin-4 isoform X1 {ECO:0000313|RefSeq:XP_007523250.1};
GN Name=NTN4 {ECO:0000313|RefSeq:XP_007523250.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007523250.1};
RN [1] {ECO:0000313|RefSeq:XP_007523250.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_007523250.1; XM_007523188.2.
DR AlphaFoldDB; A0A1S2ZR32; -.
DR STRING; 9365.ENSEEUP00000001328; -.
DR CTD; 59277; -.
DR eggNOG; KOG0994; Eukaryota.
DR InParanoid; A0A1S2ZR32; -.
DR OrthoDB; 2916807at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03578; NTR_netrin-4_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR035811; Netrin-4_NTR.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF282; NETRIN-4; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010277117"
FT DOMAIN 30..261
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 332..394
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 395..448
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 506..627
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 362..371
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 422..431
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 628 AA; 69845 MW; A8C43F5D8F0075C4 CRC64;
MGGCAPLLLL WGCSAVAAGL SGVQRTSSRC EKACNPRMGN LALGRKLWAD TTCGQNATEL
YCFYNGNTHL TCQQPKCDKC NAAQPHLAHL PAAMADSSFR FPRTWWQSAE DVHREKIQLD
LEAEFYFTHL IMVFKSPRPA AMVLERSQDF GKTWKPYKYF ATNCSATFGL DDDVDMKGAI
CTSKYSNPFP CSGGEVIFRA LSPPYDTENP YGMKAQEQLK ITNLRVQLLK RQSCPCQRND
LDAKPQHFTH YAVYDFIVKG SCFCNGHADQ CVPVDGFRPV KAPGTFHVVN GKCMCKHNTA
GSHCGHCAPL YNDRPWKAAD GKTGSPNECR TCKCNGHADT CHFDINVWEA SGNRSGGVCN
NCQHNTEGQH CQRCKPGFYR DLRRPFSAPD ACKSCSCHPV GSAVLPFNSV TFCDPSNGDC
PCKPGVAGPR CDRCMVGYWG FGDHGCRPCD CAGSCDPLTG DCISSNTDID WYHEIPDFSS
IYNKSEPAWE WEDEQGFSAL RHSGKCDCKE QELGNPKVFC GMKYSYVLKI KILSAHDKGS
HAEVNVKIKK VLKSTKLKIL RGKRTLYPES WTSRGCTCPV LNPGLEYLVA GHEDVRTGKL
IVNMKSFVQH WKPHLGRKVM DILKRECK
//
