ID A0A1S2ZRU2_ERIEU Unreviewed; 454 AA.
AC A0A1S2ZRU2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=UDP-glucuronosyltransferase {ECO:0000256|RuleBase:RU362059};
DE EC=2.4.1.17 {ECO:0000256|RuleBase:RU362059};
GN Name=LOC103113914 {ECO:0000313|RefSeq:XP_007523580.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007523580.1};
RN [1] {ECO:0000313|RefSeq:XP_007523580.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|RuleBase:RU362059};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362059}; Single-
CC pass membrane protein {ECO:0000256|RuleBase:RU362059}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR RefSeq; XP_007523580.1; XM_007523518.2.
DR AlphaFoldDB; A0A1S2ZRU2; -.
DR OrthoDB; 382054at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF12; UDP-GLUCURONOSYLTRANSFERASE 2B17-RELATED; 1.
DR Pfam; PF00201; UDPGT; 2.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362059};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|RuleBase:RU362059};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362059};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362059}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT CHAIN 22..454
FT /note="UDP-glucuronosyltransferase"
FT /evidence="ECO:0000256|RuleBase:RU362059"
FT /id="PRO_5010006000"
FT TRANSMEM 418..441
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362059"
SQ SEQUENCE 454 AA; 51866 MW; CD4C747E491D46A4 CRC64;
MPMKCVLVPL LLQLACYFSS GKCGKVLVWP TEYSHWMNIK TILDELVQRG HEVTVLTSSA
SILIDPSKPS TIKFETYPTS VTKDEFDHVF MEVIHTWTYE MPKDAFWSYF SIMEEIGWKF
HAVVYKLCRE AVLNKNLMMK LQESKFDLVL SDPYLLCILL LFYATGRPTT LLETMKKAEI
WLIRTYWDFE FPRPFLPNFE FIGGLHCKPA KPLPKEMEQF VQSSGENGIV VFTLGSMVRN
MSEETANMIA SGLAQIPQKV LWRFEGKKPD TLGKNTRLFK WLPQNDLLGH PKTKAFITHG
GTNGIYEAIY HGVPMVGIPL FADQPDNIAH MKAKGAAVGL NLDTMSSKDL LSALKTVIND
PSYKENAMKL SRIHHDQPVK PLDRAVFWIE FVMRHKGAKH LRPAVHDLTW VQYHSLDVLG
FLLACVTATV YIITASCLFC FRKCTKSGKR EKRD
//
