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Database: UniProt
Entry: A0A1S2ZTK2_ERIEU
LinkDB: A0A1S2ZTK2_ERIEU
Original site: A0A1S2ZTK2_ERIEU 
ID   A0A1S2ZTK2_ERIEU        Unreviewed;       328 AA.
AC   A0A1S2ZTK2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Voltage-dependent calcium channel gamma-4 subunit {ECO:0000256|RuleBase:RU363085};
GN   Name=CACNG4 {ECO:0000313|RefSeq:XP_007524342.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007524342.1};
RN   [1] {ECO:0000313|RefSeq:XP_007524342.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC       contain CACNA1C as pore-forming subunit (By similarity). Regulates the
CC       trafficking and gating properties of AMPA-selective glutamate receptors
CC       (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the
CC       cell membrane and synapses and modulates their gating properties by
CC       slowing their rates of activation, deactivation and desensitization and
CC       by mediating their resensitization. {ECO:0000256|RuleBase:RU363085}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC   -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC       {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR   RefSeq; XP_007524342.1; XM_007524280.2.
DR   AlphaFoldDB; A0A1S2ZTK2; -.
DR   GeneID; 103114582; -.
DR   CTD; 27092; -.
DR   eggNOG; ENOG502QPQH; Eukaryota.
DR   InParanoid; A0A1S2ZTK2; -.
DR   OrthoDB; 2957055at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   InterPro; IPR005423; VDCC_g4su.
DR   InterPro; IPR008368; VDCC_gsu.
DR   PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR   PANTHER; PTHR12107:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01792; VDCCGAMMA.
DR   PRINTS; PR01603; VDCCGAMMA4.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU363085};
KW   Calcium channel {ECO:0000256|RuleBase:RU363085};
KW   Calcium transport {ECO:0000256|RuleBase:RU363085};
KW   Ion channel {ECO:0000256|RuleBase:RU363085};
KW   Ion transport {ECO:0000256|RuleBase:RU363085};
KW   Membrane {ECO:0000256|RuleBase:RU363085};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Transmembrane {ECO:0000256|RuleBase:RU363085};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW   Transport {ECO:0000256|RuleBase:RU363085};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT   TRANSMEM        7..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        109..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        138..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   TRANSMEM        181..207
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363085"
FT   REGION          226..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   328 AA;  36703 MW;  7EE9E6CFE8073A0A CRC64;
     MVRYDRGLQM LLTTAGAFAA FSLMAIAVGT DYWLYSSAHI CNGTNLTMDE APPPRRARGD
     LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL
     GGLCIAAGRF YSRRNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPGDK RDEDKKSHYN
     YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTRRE FLKAPSSSSP YARMPSYRYR
     RRRSRSSSRS TEASPSRDAS PVGLKITGAI PMGELSMYTL SREPLKVTTA ASYSPDQEAS
     FLQVHDFFQQ DLKEGLHVSM LNRRTTPV
//
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