ID A0A1S2ZTK2_ERIEU Unreviewed; 328 AA.
AC A0A1S2ZTK2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Voltage-dependent calcium channel gamma-4 subunit {ECO:0000256|RuleBase:RU363085};
GN Name=CACNG4 {ECO:0000313|RefSeq:XP_007524342.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007524342.1};
RN [1] {ECO:0000313|RefSeq:XP_007524342.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Regulates the activity of L-type calcium channels that
CC contain CACNA1C as pore-forming subunit (By similarity). Regulates the
CC trafficking and gating properties of AMPA-selective glutamate receptors
CC (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the
CC cell membrane and synapses and modulates their gating properties by
CC slowing their rates of activation, deactivation and desensitization and
CC by mediating their resensitization. {ECO:0000256|RuleBase:RU363085}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363085}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363085}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
CC {ECO:0000256|ARBA:ARBA00007111, ECO:0000256|RuleBase:RU363085}.
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DR RefSeq; XP_007524342.1; XM_007524280.2.
DR AlphaFoldDB; A0A1S2ZTK2; -.
DR GeneID; 103114582; -.
DR CTD; 27092; -.
DR eggNOG; ENOG502QPQH; Eukaryota.
DR InParanoid; A0A1S2ZTK2; -.
DR OrthoDB; 2957055at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR005423; VDCC_g4su.
DR InterPro; IPR008368; VDCC_gsu.
DR PANTHER; PTHR12107; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNIT; 1.
DR PANTHER; PTHR12107:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNIT; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01792; VDCCGAMMA.
DR PRINTS; PR01603; VDCCGAMMA4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU363085};
KW Calcium channel {ECO:0000256|RuleBase:RU363085};
KW Calcium transport {ECO:0000256|RuleBase:RU363085};
KW Ion channel {ECO:0000256|RuleBase:RU363085};
KW Ion transport {ECO:0000256|RuleBase:RU363085};
KW Membrane {ECO:0000256|RuleBase:RU363085};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transmembrane {ECO:0000256|RuleBase:RU363085};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363085};
KW Transport {ECO:0000256|RuleBase:RU363085};
KW Voltage-gated channel {ECO:0000256|RuleBase:RU363085}.
FT TRANSMEM 7..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 138..161
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT TRANSMEM 181..207
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363085"
FT REGION 226..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 328 AA; 36703 MW; 7EE9E6CFE8073A0A CRC64;
MVRYDRGLQM LLTTAGAFAA FSLMAIAVGT DYWLYSSAHI CNGTNLTMDE APPPRRARGD
LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL
GGLCIAAGRF YSRRNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPGDK RDEDKKSHYN
YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTRRE FLKAPSSSSP YARMPSYRYR
RRRSRSSSRS TEASPSRDAS PVGLKITGAI PMGELSMYTL SREPLKVTTA ASYSPDQEAS
FLQVHDFFQQ DLKEGLHVSM LNRRTTPV
//