ID A0A1S2ZTL8_ERIEU Unreviewed; 841 AA.
AC A0A1S2ZTL8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=GALNT5 {ECO:0000313|RefSeq:XP_007524368.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007524368.1};
RN [1] {ECO:0000313|RefSeq:XP_007524368.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|RuleBase:RU361242}.
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DR RefSeq; XP_007524368.1; XM_007524306.2.
DR AlphaFoldDB; A0A1S2ZTL8; -.
DR CTD; 11227; -.
DR eggNOG; KOG3736; Eukaryota.
DR InParanoid; A0A1S2ZTL8; -.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF130; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 5; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242}.
FT DOMAIN 710..836
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
FT REGION 259..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 841 AA; 95942 MW; E14B1B61E8D60133 CRC64;
MNKIRKFFRG SGRFLMFIFV ASVIWLLFDM AALRLSFRDI NKEDILRRGW KGLRAGPDHS
IKDMKPPMKR SGKVLWAQEN WRKTEGADLD KFQKKNKIHK IPERGKAAHL QDSAPQQIPP
MTLIREEKEG RHMGTEPSSH TMTPRHRPAL QIQETLSVAT RGMPFVKIPA STGSRAIRQE
GLKSPGLNRD TSKQALGRDL DEATSFPADK PTRPLVSASR EALNDTESQS KMLNAKENEV
HRNLPFSQVI GNSVQVKKQS DGTPLEDFPA KEQGTQVGGG QELSFSDSHV VVITKEEEKT
STKEVPATES KALFSLVLDE DQRKQIPRNR NDTHFSLLAL QRAAVSQINQ TLSGAPEPAR
AKLTAKFQSV QHSQHKVKIP QPEDPGMHRV LQIDVTVSPR DPKAPGQFGR PVVVPLGKEK
EAERRWKEGN FNVYLSDLIP VDRAIEDTRP AGKETLAYST LLATQDIAWA MLMNSTYLED
SCDVLTFLDS HVECNIGWLE PLLERVYLSK NKVACPVIEV ISDKDMSYMT VDNFQRGIFV
WPMNFAWRTI PPDVVAKNRI KETDIIRCPV MAGGLFSIDK NYFFELGTYD HGLDVWGGEN
MELSFKVWMC GGEIEIIPCS RVGHIFRNDN PYSFPRDRMR TVERNLVRVA EVWLDEYKDL
FYGHGDHLMD QELQVGDLSQ QRELRKKLRC KSFKWYLEHV FPDLKAPAVR ATGVLINVEL
GKCISIENAT AALEECDRSK QLQQFNYTWL RLIKHRESCL APIPDNGTLE LHPCDDRNKG
IKWLHKSTSV FHPELVNHIV FENYHQLLCL EGNLSQKILK VVACDPMKSN QKWRFENYYE
A
//
