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Database: UniProt
Entry: A0A1S2ZTL9_ERIEU
LinkDB: A0A1S2ZTL9_ERIEU
Original site: A0A1S2ZTL9_ERIEU 
ID   A0A1S2ZTL9_ERIEU        Unreviewed;       443 AA.
AC   A0A1S2ZTL9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 10.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   Name=ACVR1C {ECO:0000313|RefSeq:XP_007524358.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae;
OC   Erinaceinae; Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007524358.1};
RN   [1] {ECO:0000313|RefSeq:XP_007524358.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|RuleBase:RU000304}.
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DR   RefSeq; XP_007524358.1; XM_007524296.1.
DR   STRING; 9365.XP_007524358.1; -.
DR   GeneID; 103114596; -.
DR   CTD; 130399; -.
DR   OrthoDB; 776697at2759; -.
DR   Proteomes; UP000079721; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000079721};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179,
KW   ECO:0000313|RefSeq:XP_007524358.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW   Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304,
KW   ECO:0000256|SAAS:SAAS00138186};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     64     86       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      115    144       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      145    437       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   443 AA;  49861 MW;  BC96AA9DFCD89F19 CRC64;
     MLSNGKEQVI KSCVSLTELN AQVFCHSSNN VTKTECCYTD FCNNKTLHLP KASPNVPTLG
     PTKLTVVITV PVCLLSAAVV LAMWACQGRQ YRDRKRRRQN VEEALSDCNL VNAGKTLKDL
     IYDTTASGSG SGLPLLVQRT IARTIVLQEL VGKGRFGEVW HGRWCGEDVA VKIFSSRDER
     SWFREAEIYQ TAMLRHENIL GFIAADNKDN GTWTQLWLVS DYHELGSLYD YLNRNIVTVA
     GMVRLAFSIA SGLAHLHMEI VGTQGKPAIA HRDIKSKNIL VKKCETCVIA DLGLAVKHDS
     MLNTIDIPQN PKVGTKRYMA PEMLDDTMNV SIFESFKRAD IYSAGLVYWE IARRCSVGGI
     VEEYQLPYYD MVPSDPSTED MRKVVCEQKF RPNIPNQWQS CEALRVMGRI MRECWYANGA
     ARLTALRIKK TISQLYIKED CKA
//
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