ID A0A1S2ZVC2_ERIEU Unreviewed; 860 AA.
AC A0A1S2ZVC2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|RefSeq:XP_007525140.1};
GN Name=PMS2 {ECO:0000313|RefSeq:XP_007525140.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007525140.1};
RN [1] {ECO:0000313|RefSeq:XP_007525140.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_007525140.1; XM_007525078.2.
DR AlphaFoldDB; A0A1S2ZVC2; -.
DR STRING; 9365.ENSEEUP00000012869; -.
DR GeneID; 103115319; -.
DR CTD; 5395; -.
DR eggNOG; KOG1978; Eukaryota.
DR InParanoid; A0A1S2ZVC2; -.
DR OrthoDB; 4698638at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Endonuclease {ECO:0000313|RefSeq:XP_007525140.1};
KW Hydrolase {ECO:0000313|RefSeq:XP_007525140.1};
KW Nuclease {ECO:0000313|RefSeq:XP_007525140.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 227..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 673..817
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 393..415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 451..478
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 495..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 537..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 860 AA; 95121 MW; B80A59F4847EE318 CRC64;
MERAAEPSAE LAKVIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIELRLKD
HGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQDFADLTR VETFGFRGEA LSSLCALSNV
TISTRHASAA VGTRLTFDHN GRITQKSPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
FARMVQVLQA YCIISTGVRL SCTNQVGAGK RQPVVATTGS ASVKENIGSV FGQKQLQSLI
PFVQLPPSDP VCEEFGLSCS DALHNLLSIS GFISHCAHGV GRSSADRQFF FINRRPCDPA
KVCRLVNEVY HGYNRHQYPF VVLNISVHSE CVDINVTPDK RQILLQEEKL LLAVLKTSLL
AMFDSDANKL NVSQQPLLDI EGNLLKMHST EMEALPSETQ DHRASPGLGG EEKRAASISR
LREAFSLRHP LGNTVQGSRT TDPKRVSPRQ KRSPLSCSTG KTLFFQKSVL STDFPSPQDK
GSCDLPDRAD RQRDSGYNSI STSSEEGAST PEMGSLSSSN PAGCSPKDEF LQENTESQEK
SPDTGSFSDS TCQLGPEQGG CKGRDLPQPT GVSAPNMKRL KREEIPQEAA APQNVSASQA
DVAVKISKKI TPLNFSMSSL TKRIKHLHHQ QQQRESEQNY RKFRAKICPG ENQAAEEELR
KEISKAMFAE MEVIGQFNLG FIITKLHADL FIVDQHATDE KYNFEMLQQH TVLQGQRLIT
PQTLHLTAVN EAVLIENLDI FRKNGFDFVI NDSAPVTKRA KLVSLPTSKN WTFGVQDIDE
LIFMLSDSPG IMCRPSRVRQ MFASRACRKS VMIGTALNTG EMKKLISHMG QMDHPWNCPH
GRPTMRHLAN LDVLSRATAQ
//