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Database: UniProt
Entry: A0A1S2ZVC2_ERIEU
LinkDB: A0A1S2ZVC2_ERIEU
Original site: A0A1S2ZVC2_ERIEU 
ID   A0A1S2ZVC2_ERIEU        Unreviewed;       860 AA.
AC   A0A1S2ZVC2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Mismatch repair endonuclease PMS2 {ECO:0000313|RefSeq:XP_007525140.1};
GN   Name=PMS2 {ECO:0000313|RefSeq:XP_007525140.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007525140.1};
RN   [1] {ECO:0000313|RefSeq:XP_007525140.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000256|ARBA:ARBA00006082}.
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DR   RefSeq; XP_007525140.1; XM_007525078.2.
DR   AlphaFoldDB; A0A1S2ZVC2; -.
DR   STRING; 9365.ENSEEUP00000012869; -.
DR   GeneID; 103115319; -.
DR   CTD; 5395; -.
DR   eggNOG; KOG1978; Eukaryota.
DR   InParanoid; A0A1S2ZVC2; -.
DR   OrthoDB; 4698638at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03484; MutL_Trans_hPMS_2_like; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF52; MISMATCH REPAIR ENDONUCLEASE PMS2; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Endonuclease {ECO:0000313|RefSeq:XP_007525140.1};
KW   Hydrolase {ECO:0000313|RefSeq:XP_007525140.1};
KW   Nuclease {ECO:0000313|RefSeq:XP_007525140.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          227..364
FT                   /note="DNA mismatch repair protein S5"
FT                   /evidence="ECO:0000259|SMART:SM01340"
FT   DOMAIN          673..817
FT                   /note="MutL C-terminal dimerisation"
FT                   /evidence="ECO:0000259|SMART:SM00853"
FT   REGION          393..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..576
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..478
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..555
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   860 AA;  95121 MW;  B80A59F4847EE318 CRC64;
     MERAAEPSAE LAKVIKPIDR KSVHQICSGQ VVLSLSTAVK ELVENSLDAG ATNIELRLKD
     HGVDLIEVSD NGCGVEEENF EGLTLKHHTS KIQDFADLTR VETFGFRGEA LSSLCALSNV
     TISTRHASAA VGTRLTFDHN GRITQKSPYP RPRGTTVSVQ QLFSTLPVRH KEFQRNIKKE
     FARMVQVLQA YCIISTGVRL SCTNQVGAGK RQPVVATTGS ASVKENIGSV FGQKQLQSLI
     PFVQLPPSDP VCEEFGLSCS DALHNLLSIS GFISHCAHGV GRSSADRQFF FINRRPCDPA
     KVCRLVNEVY HGYNRHQYPF VVLNISVHSE CVDINVTPDK RQILLQEEKL LLAVLKTSLL
     AMFDSDANKL NVSQQPLLDI EGNLLKMHST EMEALPSETQ DHRASPGLGG EEKRAASISR
     LREAFSLRHP LGNTVQGSRT TDPKRVSPRQ KRSPLSCSTG KTLFFQKSVL STDFPSPQDK
     GSCDLPDRAD RQRDSGYNSI STSSEEGAST PEMGSLSSSN PAGCSPKDEF LQENTESQEK
     SPDTGSFSDS TCQLGPEQGG CKGRDLPQPT GVSAPNMKRL KREEIPQEAA APQNVSASQA
     DVAVKISKKI TPLNFSMSSL TKRIKHLHHQ QQQRESEQNY RKFRAKICPG ENQAAEEELR
     KEISKAMFAE MEVIGQFNLG FIITKLHADL FIVDQHATDE KYNFEMLQQH TVLQGQRLIT
     PQTLHLTAVN EAVLIENLDI FRKNGFDFVI NDSAPVTKRA KLVSLPTSKN WTFGVQDIDE
     LIFMLSDSPG IMCRPSRVRQ MFASRACRKS VMIGTALNTG EMKKLISHMG QMDHPWNCPH
     GRPTMRHLAN LDVLSRATAQ
//
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