ID A0A1S2ZX71_ERIEU Unreviewed; 1017 AA.
AC A0A1S2ZX71;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dyslexia-associated protein KIAA0319 homolog isoform X2 {ECO:0000313|RefSeq:XP_007525988.1};
GN Name=KIAA0319 {ECO:0000313|RefSeq:XP_007525988.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007525988.1};
RN [1] {ECO:0000313|RefSeq:XP_007525988.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_007525988.1; XM_007525926.2.
DR AlphaFoldDB; A0A1S2ZX71; -.
DR CTD; 9856; -.
DR OrthoDB; 3021035at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00146; PKD; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029865; KIAA0319-like.
DR InterPro; IPR013980; MANSC_dom.
DR InterPro; IPR011106; MANSC_N.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR PANTHER; PTHR46182:SF1; DYSLEXIA-ASSOCIATED PROTEIN KIAA0319; 1.
DR PANTHER; PTHR46182; FI19480P1; 1.
DR Pfam; PF18911; PKD_4; 1.
DR SMART; SM00765; MANEC; 1.
DR SMART; SM00089; PKD; 4.
DR SUPFAM; SSF49299; PKD domain; 4.
DR PROSITE; PS50986; MANSC; 1.
DR PROSITE; PS50093; PKD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1017
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010359923"
FT DOMAIN 24..99
FT /note="MANSC"
FT /evidence="ECO:0000259|PROSITE:PS50986"
FT DOMAIN 547..620
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT REGION 173..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..271
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1017 AA; 111763 MW; 28A711727CEB8F8D CRC64;
MASLTGALSS LLLLVIIAGC ACMQCSDRRM YSNAVISPNL ETTKIMQVSQ ATTVVDCTTA
CCDLSSCDLA WWFEGRCYLV SCLHKDSCQP KMSPIESHLT FVLRPIQRPM QMLNYGMLNR
GSPADIWGDS PEYIRKDLPF LGKDQGLEEM SEYLDDYQEQ DLLQPISKQE RRGGAEYTDW
GLPAGSDGGI NSSAIEDTDP SEGKQQEDLE PQYLDSEHHE LNESVETPPS KYSPDRRLLL
PLGTPSAGEI LETESFQLQG KSNNSSQKEV LMPSHDPLPS SLDSSTATLG TIPVLSFPPG
RTEPSTPALP TSIHPIESTA SEEPTSPTID PKTVKELTVS AGDNLIITLP ENEVELTAFV
VPAPPAETTY NYEWSLISRP VEYQGEIKEN HMQTLNLSQL SVGLYVFKVV VSGDTVFGEG
FVNVTVRPAR RVNLPPRAIV SPQIQELILP LTSALIDGSQ STDDTKIVSY HWEEIDGPFK
EKKTSDDSSV LLLSDLVAGN YTFRLTVTDS DGASDSTVAV VRVNSAVDHP PVANPGPNQT
ITLPQNSITL NGNQSSDDHQ IVLYKWSLGP GSEKKEVAMQ GVETPYLHLS AMQEGNYTFQ
LMVTDSSRQQ STSMVTVIVQ PENNRPPVAL AGPDKELFFP SEGIILATTL DGSRSTDDHG
IVFYFWEHIS GPSAVEMENI DKPIATVTGL QVGTYHFRLT VRDQQGLSSS TTLTVAVKKE
NNSPPRAQAG GRHVLVLPNN SITLDGSRST DDQGIVSYQW IRDGQSPAAG DVLEGSDGSA
SLQLTNLVEG VYTFHLRVAD GQGALDTDTT TVEVQPDPRK RDLVELILQV SVGKLTEQQK
DILVRQLALL LNVLDSDIKV QKIQAHSDLS TVIVFYVQSG PPFKVFKAAE IARNLHRRLS
RERADFLLFK VLRIDTEGCL LTCSGHGHCD PITKRCVCSQ LWMENPILHY IQDGESNCGI
KHRSTEHNSS LMVSESEFDS DQDTIFSRER MEQGNSKFSM NGSIRNGAFF NYCSKDR
//
