ID   A0A1S2ZXI4_ERIEU        Unreviewed;       705 AA.
AC   A0A1S2ZXI4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Ral guanine nucleotide dissociation stimulator-like 3 {ECO:0000313|RefSeq:XP_007526114.1};
GN   Name=RGL3 {ECO:0000313|RefSeq:XP_007526114.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526114.1};
RN   [1] {ECO:0000313|RefSeq:XP_007526114.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007526114.1; XM_007526052.2.
DR   AlphaFoldDB; A0A1S2ZXI4; -.
DR   GeneID; 103116189; -.
DR   CTD; 57139; -.
DR   eggNOG; KOG3629; Eukaryota.
DR   InParanoid; A0A1S2ZXI4; -.
DR   OrthoDB; 68574at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd00155; RasGEF; 1.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00314; RA; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00720; RASGEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          61..196
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          248..506
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   DOMAIN          607..694
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          1..51
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..421
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        407..421
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        551..598
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  77291 MW;  17CEFC99927A38DC CRC64;
     MEHAADKELT LPPLQDWGEE EEDGAVYSVS LRRQRSQRGS PGAEPGGSQA VPGFLHYRTS
     KVRALRAAHL ERLVWELVLG DREQDPSFVP AFLATHQAFA PTARVLNLLL PPPPPPLPMG
     SVVKKSEDWD LALNRNLRSV VLVLGSWLRD HPQDFRGHPA HEDLQKVQKF LGWASPAGPE
     AQEAEKLLRE FLAEAEQGGR EEDQTQVWTG PQSGAQARNP NTPEGFLEEE VREEDSLVRS
     GPELLDFSVD EVAEQLTLLD AELFSRVRAC ECLGSVWSQR DRPGVAGSSP TVRATVTQFN
     AVTGWVLGSV LGEPGLATPL RALRLEKWIR IAQRCRELKN FSSLHAILSA LQSNPIYRLK
     RSWGAVSREP LSAFKKLSQI FSDENNYFSC REILSQEEAA EGPPDQGSAP GDPPSPLPPG
     PVPYLGTFLT DLVMLDTALP DTLEPELINF EKRRKEWEIL ARIQQLQKRC RQYQLRPHPG
     VLAALRAQRQ LSEEQSYRVS RVIEPPAASC PSSPRIRRRI SLTKRLSAKL SRERGSSPGG
     SPGDPASPTS SLSPGSPPAS PRSRDPTPGS PPPSPGPLHP NMKLPLNPEF PGSCPPGGPR
     TPFQGSEARV IRVSLENDHG NVYRSILLTS QDKASSVVQR ALQKHGVEQP GAGAFQLLQA
     LSGDKELLIP ENANVFYAMS SRVPGDFVLR RKAAATTQGP TVSPP
//