ID   A0A1S2ZXY3_ERIEU        Unreviewed;       947 AA.
AC   A0A1S2ZXY3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Probable ATP-dependent DNA helicase DDX11 {ECO:0000313|RefSeq:XP_007526326.2};
GN   Name=DDX11 {ECO:0000313|RefSeq:XP_007526326.2};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526326.2};
RN   [1] {ECO:0000313|RefSeq:XP_007526326.2}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR   RefSeq; XP_007526326.2; XM_007526264.2.
DR   AlphaFoldDB; A0A1S2ZXY3; -.
DR   STRING; 9365.ENSEEUP00000010841; -.
DR   GeneID; 103116388; -.
DR   CTD; 1663; -.
DR   eggNOG; KOG1133; Eukaryota.
DR   InParanoid; A0A1S2ZXY3; -.
DR   OrthoDB; 124793at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd18788; SF2_C_XPD; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR045028; DinG/Rad3-like.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR006554; Helicase-like_DEXD_c2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR   InterPro; IPR013020; Rad3/Chl1-like.
DR   NCBIfam; TIGR00604; rad3; 1.
DR   PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR   PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR   Pfam; PF06733; DEAD_2; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   SMART; SM00488; DEXDc2; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806,
KW   ECO:0000313|RefSeq:XP_007526326.2};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          27..462
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51193"
FT   REGION          99..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          163..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          924..947
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          306..357
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   947 AA;  105766 MW;  3191650FB9ED90E2 CRC64;
     MTAAEISSPH QYCLCVRTMA NATEETDGIH FPFPFTPYSI QKDFMAELYR VLENGKIGIF
     ESPTGTGKSL SLICGALSWL RDFEQKQREE EKRLLEADTT ALGDGKDQPP PLSSSCQGPG
     PPRPVGEPDW VTQFVQKKEE RDLVERLKEE QLRRKRREER LQQLRHSVQL KHAAKRARQE
     EEETERLLQL SSEMLAGASG QLEPLASDEE ELVLAEYESD EDRGEKGATS GVDEDDLEEE
     HVTKIYYCSR THSQLAQFVH EVQKSPFGKD TRLVVLGSRQ NLCVNQDVRK LGAVQLMNDR
     CVEMQRRRLE RQRRAEEKEV VKRRRQEQAT PCPFHGFEQL QLLRDQLLAE VTDIEQLVAL
     GQQAQACPYY ASRLAIPAAQ LVVLPYQMLL HAATRQAAGI RLQGQVVIVD EAHNLVDTIA
     AIHGAEVSGA QLCQAHSQLL QYMDRYGKRL KAKNLMYIKQ ILYVLEKLVT VLGGNINQNP
     NTQTFSQTGT ELKSINDFLF QSQIDNINLF KVRRYCEKSM ISRKLFGFTE RQGAALTPAC
     GQPGLAGFQS FLQSLQPGVA EALTPVEQEQ QVGTPRPASP LMLIEGFLAA LTTANQDGRV
     ILSRQGSLSE SSLRFLLLNP AVHFAQVVRE CRALVIAGGT MQPVSDFREQ LLTCAGVEAE
     RVVEFSCGHV IPPDNILPLV LCSGPSGQQL EFTFQRRELP ELMHEAGRTL LNLCQVVPGG
     VVCFFPSYEY QSRVLTHWKQ RGVLGSLASR KKIFQEPKRA SQVEQVLMEY AKCIQGCGQM
     GSKVTGALLL AVVGGKMSEG INFSDDLGRC VVMVGMPFPN IKSPELQEKM AYLDRTLPRA
     PGRLPPGKVL VESLCMKAVN QSIGRAIRHQ RDFASIVLLD QRYSRPAVLA KLPTWIRQRV
     DVKASFGQAI ATLRKFHREK ASSSSSLVLP PGTQNGLSCR EGPCLKK
//