ID A0A1S2ZZ13_ERIEU Unreviewed; 591 AA.
AC A0A1S2ZZ13;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Regulator of G-protein signaling 3 isoform X2 {ECO:0000313|RefSeq:XP_007526810.1};
GN Name=RGS3 {ECO:0000313|RefSeq:XP_007526810.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526810.1};
RN [1] {ECO:0000313|RefSeq:XP_007526810.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_007526810.1; XM_007526748.1.
DR AlphaFoldDB; A0A1S2ZZ13; -.
DR CTD; 5998; -.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030695; F:GTPase regulator activity; IEA:UniProt.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd08713; RGS_RGS3; 1.
DR Gene3D; 1.10.196.10; -; 2.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR034951; RGS_RGS3.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR46848; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR PANTHER; PTHR46848:SF1; REGULATOR OF G-PROTEIN SIGNALING 3; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00615; RGS; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 18..95
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 466..582
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT REGION 207..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 391..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 66818 MW; C07BD511EBC4D0F9 CRC64;
MNRFNGLCKV CSERRYRQIT IPRGKDGFGF TICCDSPVRV QAVDSGGPAE RAGLQQLDTV
LQLNERPVEH WKCVELAHEI RSCHGEIILL VWRMVPQVKP GPDGGVLRRA SCKSAHDLLS
PPNKREKNCT HGVQARPEQR HSCHLVCDSS NGLLLGGWER YTEVTKRGGQ HTLPALSRAT
APTDPNYIIL APLNPGSQLL RPLYQEDTIP EESGSPTKGK SSYTGLGKKS RLMKTVQTMK
GHGNYQNCSI MRPHTPHSNY GTYVTLAPKV LVFPVFVQPL DLCNPARTLL LSEELLLYEG
RNKAAEVTLF AYSDLLLFTK EDEPGRCNVL RNPLYLQSVK LQEGSSDDLK FCMLYLAEKA
ECLFTLEAHS QEQKKRVCWC LSENIAKQQQ LAASPPENKM SGPDTVGDDD DASRKRKSKN
IAKDMKNKLG IFRRWNESPG AQPVGKTDKM KSFKPTSEEA LKWGESLEKL LIHKYGLAVF
QAFLRTEFSE ENLEFWLACE DFKKVKSQSK MVAKAKKIFA EYIAIQACKE VNLDSYTREH
TKDNLQSVTR NCFDLAQKRI FGLMEKDSYP RFLRSDLYLD LINQKKMSPP L
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