ID   A0A1S2ZZ39_ERIEU        Unreviewed;       526 AA.
AC   A0A1S2ZZ39;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Thymocyte selection-associated high mobility group box protein TOX {ECO:0000313|RefSeq:XP_007526791.1};
GN   Name=TOX {ECO:0000313|RefSeq:XP_007526791.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526791.1};
RN   [1] {ECO:0000313|RefSeq:XP_007526791.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_007526791.1; XM_007526729.2.
DR   AlphaFoldDB; A0A1S2ZZ39; -.
DR   STRING; 9365.ENSEEUP00000011397; -.
DR   GeneID; 103116784; -.
DR   CTD; 9760; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   InParanoid; A0A1S2ZZ39; -.
DR   OrthoDB; 4252846at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd21995; HMG-box_TOX-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR45781; AGAP000281-PA; 1.
DR   PANTHER; PTHR45781:SF4; THYMOCYTE SELECTION-ASSOCIATED HIGH MOBILITY GROUP BOX PROTEIN TOX; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PRINTS; PR00886; HIGHMOBLTY12.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          261..329
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        261..329
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          143..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          192..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   526 AA;  57563 MW;  E3B256920BFBBF7D CRC64;
     MDVRFYPPPA QPAAAPDAPC LGPSPCLDPY YCNKFDAENM YMSMTEPSQD YVPASQSYPG
     PSLESEDFNI PPITPPSLPD HSLVHLNEVE PGYHSLCHSV NHNGLLPFHP QNMELPEITV
     SNMLAQDGTL LSNSISVMQD IRNPEGTQYS PHPQMTAMRP RGQPADIRQQ PGMMQHGQLT
     TINQSQLSAQ LGLNMGGSSV PHNSPSPPGS KSATPSPSSS VHEDEGDDTS KINGGEKRPA
     SDMGKKPKTP KKKKKKDPNE PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD
     GLGEEQKQVY KKKTEAAKKE YLKQLAAYRA SLVSKSYSEP VDVKTSQPPQ LINSKPTVFH
     GPSQTHSALY LSSHYHQQPG MNPHLTAMHP SLPRSIAPKP SNQMPVTVSI ANMAVSPPPP
     LQISPPLHQH LNMQQHQPLS MQQPLGSQLP MQVQSALHSP TMQQGFTLQP DYQTIINPTS
     TAAQVVTQAM EYVRSGCRNP PAQPVDWNND YCSSGVMQRD KALYLT
//