ID A0A1S2ZZ77_ERIEU Unreviewed; 440 AA.
AC A0A1S2ZZ77;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Integral membrane protein GPR180 {ECO:0000313|RefSeq:XP_007526908.1};
GN Name=GPR180 {ECO:0000313|RefSeq:XP_007526908.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526908.1};
RN [1] {ECO:0000313|RefSeq:XP_007526908.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_007526908.1; XM_007526846.1.
DR AlphaFoldDB; A0A1S2ZZ77; -.
DR STRING; 9365.ENSEEUP00000011898; -.
DR GeneID; 103116891; -.
DR CTD; 160897; -.
DR eggNOG; KOG4290; Eukaryota.
DR InParanoid; A0A1S2ZZ77; -.
DR OrthoDB; 5391031at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..440
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010262584"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..345
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..405
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 440 AA; 49479 MW; 6043B7CD5B015829 CRC64;
MGALRLLAVA LTCCWWPPGS QGKTLWGSFS SAAARDAQGQ NVGHFEFHGD HALLCVRISN
VGIAVEKEAK LYLFQAQEWL KLQENTHDYS CSERLSKAQL TMTMNQTEHN LTVSQIPHPH
VWHVFYADKY TCKDDSENLQ VEDIPFEIIL LNPDAEGNPF DHFSAGESGL HEFFFLLVLV
YFVIACIYAQ SLWQAIKKGG PMHMILKVLT TALLLQAASA LTNYIHFSSY AKNGIGVPVM
GSLAEFFDIA SQIQMLYLLL SLCMGWTLVR MKKSQSRPLQ WDSTPASTGI AVFIVITQSI
LLLWEQFEDT SPHSYHSHRN LAGILLIVLR ICLALSLGCG LYQIVTVERS TLKREFYTTF
AKGCILWFLC HPVLAFLSVI FSDYQRDKVI TIGVILCQSA SMVILYRLFL SHSLYWEVSS
LSSVTLPLTI SSGHKSRPHF
//
