ID A0A1S2ZZI2_ERIEU Unreviewed; 318 AA.
AC A0A1S2ZZI2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Adenosine receptor A3 {ECO:0000256|ARBA:ARBA00021738, ECO:0000256|RuleBase:RU201114};
GN Name=LOC103116970 {ECO:0000313|RefSeq:XP_007526996.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007526996.1};
RN [1] {ECO:0000313|RefSeq:XP_007526996.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC mediated by G proteins which inhibit adenylyl cyclase.
CC {ECO:0000256|RuleBase:RU201114}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU201114}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU201114}.
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DR RefSeq; XP_007526996.1; XM_007526934.2.
DR AlphaFoldDB; A0A1S2ZZI2; -.
DR GeneID; 103116970; -.
DR CTD; 140; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; A0A1S2ZZI2; -.
DR OrthoDB; 2909020at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000466; Adeno_A3_rcpt.
DR InterPro; IPR001634; Adenosn_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24246:SF2; ADENOSINE RECEPTOR A3; 1.
DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00555; ADENOSINEA3R.
DR PRINTS; PR00424; ADENOSINER.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU201114};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU201114};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU201114};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW ECO:0000256|RuleBase:RU201114};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU201114};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU201114};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU201114};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU201114};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU201114}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 48..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 78..106
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 127..149
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 178..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT TRANSMEM 261..284
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU201114"
FT DOMAIN 29..282
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 318 AA; 36050 MW; DB3BB7D6371C1CB8 CRC64;
MPINSTTLSL TSITYISMEI LIGFCAIVGN VLVICVVKMN PSLQTTTFYF IVSLALADIA
VGVLVMPLAV VISLGMTIHF YNCLLMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYRR
VTTQKRIWLA LGLCWLISLL VGLTPMFGWN MKLTSGPNRN NSVLICQFRS VVRMDYMVFF
SFFTWIFIPL VVMCAIYLDI FYIIRNRLSQ NFSNTKETGA FYGREFKTAK SLFLVLFLFA
LSWLPLSITN CVLYFDVEVP PAVQFLGILL SHANSMMNPI IYACKIKKFK ETYLLIFRAC
MTCQPSDSLD SGTKQSSE
//
