ID A0A1S2ZZV7_ERIEU Unreviewed; 288 AA.
AC A0A1S2ZZV7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Palmitoyl-protein thioesterase 1 {ECO:0000256|ARBA:ARBA00014212};
DE EC=3.1.2.22 {ECO:0000256|ARBA:ARBA00012423};
DE AltName: Full=Palmitoyl-protein hydrolase 1 {ECO:0000256|ARBA:ARBA00031934};
GN Name=PPT1 {ECO:0000313|RefSeq:XP_007527170.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007527170.1};
RN [1] {ECO:0000313|RefSeq:XP_007527170.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + S-hexadecanoyl-L-cysteinyl-[protein] = H(+) +
CC hexadecanoate + L-cysteinyl-[protein]; Xref=Rhea:RHEA:19233,
CC Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:7896,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:74151; EC=3.1.2.22;
CC Evidence={ECO:0000256|ARBA:ARBA00000072};
CC -!- SIMILARITY: Belongs to the palmitoyl-protein thioesterase family.
CC {ECO:0000256|ARBA:ARBA00010758}.
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DR RefSeq; XP_007527170.1; XM_007527108.2.
DR AlphaFoldDB; A0A1S2ZZV7; -.
DR GlyCosmos; A0A1S2ZZV7; 3 sites, No reported glycans.
DR CTD; 5538; -.
DR eggNOG; KOG2541; Eukaryota.
DR InParanoid; A0A1S2ZZV7; -.
DR OrthoDB; 760135at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0008474; F:palmitoyl-(protein) hydrolase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002472; Palm_thioest.
DR PANTHER; PTHR11247:SF8; PALMITOYL-PROTEIN THIOESTERASE 1; 1.
DR PANTHER; PTHR11247; PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1; 1.
DR Pfam; PF02089; Palm_thioest; 1.
DR PRINTS; PR00414; PPTHIESTRASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..288
FT /note="Palmitoyl-protein thioesterase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010240805"
SQ SEQUENCE 288 AA; 32166 MW; 182E8097F33DF22E CRC64;
MALPSCSWLL AIVLLPGFCG ARVFGHRDPP APLPLVLWHG MGDSCCNPLS MGAIKKMVES
KIPGIYILSL EIGKTLMEDV ENSFFMNVNS QVSVVCQILA KDPEFQQGYN AMGFSQGGQF
LRAVAQRCPS PPMVNLISVG GQHQGVFGLP RCPGKSSHIC DLIRKTLNTG AYNKAIQERL
VQAEYWHDPI KEDTYRNHSI FLADINQERV FNQSYKKNLM ALKKFVMVKF LNDSVVDPVE
SEYGLFLQDL LGLKEMDKAG KLVFLAVQGD HLQVSAEWFY AHIIPFLK
//
