ID A0A1S3A1D1_ERIEU Unreviewed; 708 AA.
AC A0A1S3A1D1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Amyloid beta A4 precursor protein-binding family B member 1 isoform X2 {ECO:0000313|RefSeq:XP_007527821.1, ECO:0000313|RefSeq:XP_016045744.1};
GN Name=APBB1 {ECO:0000313|RefSeq:XP_007527821.1,
GN ECO:0000313|RefSeq:XP_016045744.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007527821.1};
RN [1] {ECO:0000313|RefSeq:XP_007527821.1, ECO:0000313|RefSeq:XP_016045744.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007527821.1; XM_007527759.2.
DR RefSeq; XP_016045744.1; XM_016190258.1.
DR GeneID; 103117653; -.
DR CTD; 322; -.
DR OrthoDB; 5404780at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0001540; F:amyloid-beta binding; IEA:InterPro.
DR CDD; cd01272; PTB1_Fe65; 1.
DR CDD; cd01271; PTB2_Fe65; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039576; APBB1/2/3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14058; AMYLOID BETA A4 PRECURSOR PROTEIN-BINDING FAMILY B; 1.
DR PANTHER; PTHR14058:SF5; AMYLOID BETA PRECURSOR PROTEIN BINDING FAMILY B MEMBER 1; 1.
DR Pfam; PF00640; PID; 2.
DR Pfam; PF00397; WW; 1.
DR SMART; SM00462; PTB; 2.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS01179; PID; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 252..284
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 370..507
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 540..697
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..174
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 76893 MW; C7DDBAE52BFF4404 CRC64;
MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL QASAVGPKDL RSAMGEGGGP
EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS QEPETVPLGP KGLMHLYSEL
EISAHNAANR GLRGPGLIIN TEDQEPDEGE EKAAGEAEED DEEEEEEEEE DLSSPPGLPE
PLESVEVPPG PQALADGPRE HSKSASLLFG MRNSAASDED SSWATLSQGS PSYGSPEDTD
SFWNPNAFET DSDLPAGWMR VQDTSGTYYW HIPTGTTQWE PPGQASSSQG SSPREDSSQL
TWTGFTHGEG FEDGEFWKDE PNEEAPMDLG IKDPEEGTLP FPAQSLSPEP LPQEEEKLPA
RNTNPGTKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ LSYHKNNLHD PMAGGWGEGK
DLLLQLEDET LKLVEPQTQA LLHAQPIVSI RVWGVGRDSG RDFAYVARDK LTQMLKCHVF
RCEAPAKNIA TSLHEICSKI MAERRNARCL VNGLSLDHSK LVDVPFQVEF PAPKNELVQK
FQVYYLGNVP VAKPVGVDVI NGALESVLSS SSREQWTPSH VSVAPATLTI LHQQTEAVLG
ECRVRFLSFL AVGRDVHTFA FIMAAGPASF CCHMFWCEPN AASLSEAVQA ACMLRYQKCL
DARSQASTSC LPAPPAESVA RRVGWTVRRG VQSLWGSLKP KRLGAHTP
//
