ID A0A1S3A203_ERIEU Unreviewed; 1325 AA.
AC A0A1S3A203;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=C-Jun-amino-terminal kinase-interacting protein 3 isoform X3 {ECO:0000313|RefSeq:XP_007528073.1};
GN Name=MAPK8IP3 {ECO:0000313|RefSeq:XP_007528073.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007528073.1};
RN [1] {ECO:0000313|RefSeq:XP_007528073.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the JIP scaffold family.
CC {ECO:0000256|ARBA:ARBA00009866}.
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DR RefSeq; XP_007528073.1; XM_007528011.2.
DR CTD; 23162; -.
DR OrthoDB; 3685563at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0005078; F:MAP-kinase scaffold activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1770; -; 1.
DR Gene3D; 1.20.5.1000; arf6 gtpase in complex with a specific effector, jip4; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039911; JIP3/JIP4.
DR InterPro; IPR032486; JIP_LZII.
DR InterPro; IPR019143; JNK/Rab-associated_protein-1_N.
DR InterPro; IPR034743; RH1.
DR InterPro; IPR034744; RH2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR13886:SF3; C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR13886; JNK/SAPK-ASSOCIATED PROTEIN; 1.
DR Pfam; PF16471; JIP_LZII; 1.
DR Pfam; PF09744; Jnk-SapK_ap_N; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS51776; RH1; 1.
DR PROSITE; PS51777; RH2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000313|RefSeq:XP_007528073.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000313|RefSeq:XP_007528073.1}.
FT DOMAIN 11..99
FT /note="RH1"
FT /evidence="ECO:0000259|PROSITE:PS51776"
FT DOMAIN 513..587
FT /note="RH2"
FT /evidence="ECO:0000259|PROSITE:PS51777"
FT REGION 181..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 718..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1245..1266
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 65..166
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 441..489
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 243..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..751
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1325 AA; 146074 MW; C2181325B0B95D43 CRC64;
MMEIQMDESG VAVYQDDYGP GSVMSERVSG LAGSIYREFE RLIRCYDEEV VKELMPLVVT
VLENLDAVLG ENQEHEVELE LLREDNEQLL TQYEREKALR KQAEEKFIEF EDALEQEKKE
LQVQVEHYEL QTRQLELKAK NYADQISRLE EREAEMKKEY NALHQRHTEM IQTYVEHIER
SKMQQVGGNS QTESSLPGRR KERPTSLNVF PLADGMVRAQ MGGQLVPAGD HWHLSDLGQL
QFSSSYQGPN DEMSESGQSS AAATPSTTGT KSNTPTSSVP SAAVTPLNEC LQPPGDYAGG
PKNGRRAREK RNSRNMEVQV TQEMRNVSIG MGSSDEWSDV QDIIDSTPEL DVVREPRLDR
TGNSPTQGIV NKAFGINTDS LYHELSTAGS EVIGDVDEGA DLLGEFSGMG KEVGNLLLEN
SQLLETKNAL NVVKNDLIAK VDQLSGEQEV LKGDLEAARQ AKLRLESRIK DLEEELRRVK
SEAITARREP KEEVEDVSSS LCTELDKIPM AQRRRFTRVE MARVLMERNQ YKERLMELQE
AVRWTEMIRA SREHPSVQEK KKSTIWQFFS RLFSSSSSPP PAKRSYPSVN IHYKSPTTAG
FSQRRNHAMC QIAGSRPLEF FPDDDCTSSA RREQKREQYR QVREHVRNDD GRLQACGWSL
PAKYKQLSPN GGQEDTRMKN VPVPVYCRPL VEKDPTMKLW CAAGVNLSGW RPIEEDPAAT
VKSVPGRDPL TCDREAEGEP KSSHTSPEKK VKELVEADAT CSRVWVLTST LTTSKVVIID
ANQPGTVVDQ FTVCNAHVLC ISSIPAASDS DYPPGEIFLD SDVNPEDSGA DGVLAGITLV
GCATRCNVPR SNCSSRGDTP VLDKSRGEVA AVANGKVNPA QSTEEATEAT EVPDSGSSEA
DTAAVRPGPL TEHVFTDPTP TPTPSAPPGS EPEVEMSGAP PEQEPSAEPA GPCSSAAPTM
WLGAQNGWLY VHSAVANWNK CLHSIKLKDS VLSLVHVKGR VLVALADGTL AIFHRGEDGQ
WDLSNYHLMD LGHPHHSIRC MAVVYDRVWC GYKNKVHVIQ PKTMQIEKSF DAHPRRESQV
RQLAWIGDGV WVSIRLDSTL RLYHAHTHQH LQDVDIEPYV SKMLGTGKLG FSFVRITALL
IAGNRLWVGT GNGVVISIPL TETVVLHRGQ LLGLRANKTS PTSGEGARPG GVIHVYGDDP
SDKSASSFIP YCSMAQAQLC FHGHRDAVKF FVSVPGNVLA TLNGSVLDSP SEGPGPAAPA
SDPESQKLKS ALVLSGGEGY IDFRIGDGED DEAEESVGDI GQVKPVLSKA ERSHIIVWQV
SYAPE
//
