ID A0A1S3A3B1_ERIEU Unreviewed; 670 AA.
AC A0A1S3A3B1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Kelch repeat and BTB domain-containing protein 6 {ECO:0000313|RefSeq:XP_007528679.1};
GN Name=LOC103118402 {ECO:0000313|RefSeq:XP_007528679.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007528679.1};
RN [1] {ECO:0000313|RefSeq:XP_007528679.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_007528679.1; XM_007528617.2.
DR AlphaFoldDB; A0A1S3A3B1; -.
DR STRING; 9365.ENSEEUP00000004269; -.
DR GeneID; 103118402; -.
DR CTD; 89890; -.
DR eggNOG; ENOG502QWK2; Eukaryota.
DR InParanoid; A0A1S3A3B1; -.
DR OMA; FISFDLM; -.
DR OrthoDB; 5472491at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0035020; P:regulation of Rac protein signal transduction; IEA:Ensembl.
DR CDD; cd18273; BTB_POZ_KBTBD6_7; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR046790; KBTB_W-LIR.
DR InterPro; IPR047933; KBTBD6_7_BTB_POZ.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF385; KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF20165; KBTB_W-LIR; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 2.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 63..138
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 670 AA; 75632 MW; 3E98547B123E6327 CRC64;
MQSREEAQRS RRLASPRGGK RPKRIHKPTV SAFFTGPEEL KDAAHSAALL AQLKSFYDAR
LLCDVTIEVV TPGSGPGTGR LFPCNRNVLA AACPYFKSMF TGGMYESQQT SVTMHDVDAE
SFEVLVDYCY TGRVSLSEAN VERLYAASDM LQLEYVREAC ASFLARRLDL TNCTAIFKFA
DAFGHRKLRS QAQAFIAHNF KQLSQMSSIR EETLADLTLA QMLTVLRLDS LNIEHEQTVC
HVAVQWLEAA PKERGPSAAE VFKCVRWTHF ADQDQDYLKG LLANTIVKKH CLDLIEGALQ
MRYGDMLCKS LVPKPEASSS SSVVPAVESP PQRLGVCAKK MVILFGHPRD PFLCCDPYSG
DIYKVPSPVT CLAHTRSVTT LAVCVSPDHD IYLAPQPRKD LWVYKPAQNS WQQLADRLLC
REGMDVAYLN GYIYILGGRD PITGVKLKEV ECYSVQRNQW VMVAPLPHSF ISFDLMVIQN
YLYALNSKRM FCFDPSHNIW LKCVSLKRND FQEACVFNDE IYCICDIPVM KVYNPVRGEW
RQMNNIPLVS ETNNYRIITH GQKLLLITSR TPQWKKNRVT VYEYDLVTDQ WINIGSTLGL
FQFDSNFFCL SSRVYPSCLE SGESFLTEEE EVPSESSTEW DLGGFSELDS ESGSSSSLSD
DDLWVQVAPQ
//
