ID A0A1S3A406_ERIEU Unreviewed; 260 AA.
AC A0A1S3A406;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Endoplasmic reticulum resident protein 29 {ECO:0000256|ARBA:ARBA00014173, ECO:0000256|PIRNR:PIRNR027352};
GN Name=ERP29 {ECO:0000313|RefSeq:XP_007528978.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007528978.1};
RN [1] {ECO:0000313|RefSeq:XP_007528978.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Does not seem to be a disulfide isomerase.
CC {ECO:0000256|PIRNR:PIRNR027352}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR027352}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC {ECO:0000256|PIRNR:PIRNR027352}. Melanosome
CC {ECO:0000256|PIRNR:PIRNR027352}.
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DR RefSeq; XP_007528978.1; XM_007528916.2.
DR AlphaFoldDB; A0A1S3A406; -.
DR STRING; 9365.ENSEEUP00000011101; -.
DR GeneID; 103118706; -.
DR CTD; 10961; -.
DR eggNOG; ENOG502QSHC; Eukaryota.
DR InParanoid; A0A1S3A406; -.
DR OMA; KYVLVKF; -.
DR OrthoDB; 5403558at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
DR GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0050709; P:negative regulation of protein secretion; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR CDD; cd00238; ERp29c; 1.
DR CDD; cd03007; PDI_a_ERp29_N; 1.
DR Gene3D; 1.20.1150.12; Endoplasmic reticulum resident protein 29, C-terminal domain; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR016855; ERp29.
DR InterPro; IPR011679; ERp29_C.
DR InterPro; IPR036356; ERp29_C_sf.
DR InterPro; IPR012883; ERp29_N.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12211; ENDOPLASMIC RETICULUM PROTEIN ERP29; 1.
DR PANTHER; PTHR12211:SF0; ENDOPLASMIC RETICULUM RESIDENT PROTEIN 29; 1.
DR Pfam; PF07749; ERp29; 1.
DR Pfam; PF07912; ERp29_N; 1.
DR PIRSF; PIRSF027352; ER_p29; 1.
DR SUPFAM; SSF47933; ERP29 C domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|PIRNR:PIRNR027352};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..260
FT /note="Endoplasmic reticulum resident protein 29"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010327933"
FT DOMAIN 32..154
FT /note="ERp29 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF07912"
FT DOMAIN 155..250
FT /note="Endoplasmic reticulum resident protein 29 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF07749"
SQ SEQUENCE 260 AA; 29108 MW; 179666E0AE081679 CRC64;
MAAAAPRSTS LLPLFPLLCL LLLSAPQGGS GLHTKGALPL DTITFYKVIP KSKFVLVKFD
TQYPYGEKQD EFKRLAENSA SNDDLLVAEV GISDYGDKLN MELSEKYKLD KENYPVFYLF
RDGDFENPLL YSGAVKVGAI QRWLKGQGVY LGMPGCLPLY DALASEFIRA SDTEARRTLL
KRGQDSLASV KETEKKWAEQ YLKIMGKVLD QGEDFPASEM TRITKLIEKN KMSDGKKEEL
QKSLNILTAF QKKGGEKEEL
//
