ID   A0A1S3A419_ERIEU        Unreviewed;      1851 AA.
AC   A0A1S3A419;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=von Willebrand factor A domain-containing protein 8 {ECO:0000313|RefSeq:XP_007529014.1};
GN   Name=VWA8 {ECO:0000313|RefSeq:XP_007529014.1};
OS   Erinaceus europaeus (Western European hedgehog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC   Erinaceus.
OX   NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007529014.1};
RN   [1] {ECO:0000313|RefSeq:XP_007529014.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_007529014.1; XM_007528952.2.
DR   STRING; 9365.ENSEEUP00000010216; -.
DR   CTD; 23078; -.
DR   eggNOG; KOG1808; Eukaryota.
DR   InParanoid; A0A1S3A419; -.
DR   OrthoDB; 37271at2759; -.
DR   Proteomes; UP000079721; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd00009; AAA; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039891; VWA8.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR21610; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR   PANTHER; PTHR21610:SF9; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF07728; AAA_5; 3.
DR   SMART; SM00382; AAA; 2.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT   DOMAIN          1660..1842
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          1488..1508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1492..1506
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1851 AA;  208186 MW;  D5443A5B3B958248 CRC64;
     MGDTVSIGDV SYKLKTPKSP ELVPQNYISD SLAQSVIHHL RWIMQKDILG QDIFLIGPPG
     PLRRSIAMQY LELTKREVEY IALSRDTTET DLKQRREIRA GTAFYIDQCA VRAAMEGRTL
     VLEGLEKAER NVLPVLNNLL ENREMQLEDG RFLMSAERYD KLLQEHTKTE LDSWKIVRVS
     ENFRVIALGL PVPKYSGNPL DPPLRSRFQA RDIYYLPFKD QLKLLYSVGP NISAEKISQL
     LSFATTLCSQ ESSTLGLPDF PLDSLPAAVQ ILDSFPRMSI KHAIHWLYPY TILLGHEGKM
     AVEDVLKRFE LQDPASSELP KEILRVERLT GHGVSRALVT VQIADKEVTI KVPAGTKPLS
     QPCGSDCFIQ TLSHRQLLAE MMQSHMVKDI CLIGGKGCGK TVIAKNFADT LGYNIEPIML
     YQDMTARDLL QQRYTLPNGD TAWRASPLIT AALEGKLVLL DGIHRVNAGT LAVLQRLIHD
     RELSLYDGSR LLREDRYSRL KEELQLSDEQ LQKRLIFPVH PSFRIIALAE PPVVGSSTQQ
     WLGPEFLTMF FFHHMKPLVK SEELQVIKEM VPNIPQESLD KLLSFTHKLR DTQDPTAQSL
     AASLSTRQLL RISRRLSQYP NENLHSAVNK ACLSRFLPSL ARSALEKNLA DAGIGIHKDN
     QEPELENYKC EVTSGSLRIG AVSAPVYNAH EKMKVPDVLF YDNIQHMIVM EDMLKDFLLG
     EHLLLVGNQG VGKNKIVDRF LHLLNRPREY IQLHRDTTVQ TLTLQPSVKD GLIVYEDSPL
     VKAVKLGHIL VVDEADKAPT NVTCILKTLV ESGEMILADG RRIIANSANV NGRENIIVIH
     PDFRMIVLAN RPGFPFLGND FFGTLGDIFG CHAVDNPKPH SELEMLRQYG PDVPEPILQK
     LVAAFGELRN LADQGIINYP YSTREIVNIV KHLQKFPTEG LSTVVRNVFD FDSYNSDMRE
     TLISTLHKYG IPIGAKPTSV QLAKELPLPE QSFMGYWTIG QSRNGTQKLL CPAETDQISV
     KGPAPINIQK YPIERHEERS LTFTEECASW KLPLDEINLI CDIATSHENG ENTLYAVACN
     PVSLYFMNMD GKNGYFVDLY DIFPRTASGV WHPFVTVAPL GNPLKGQVIL HEQQSNVILL
     LDTTTQTLRR LALPSEEVTS KQTSWWNKET KESYNMCKEF SHKNWLVFYK EKGNNLTVLD
     VLEGRTHTIS LPIYLKSVFL VAEDKWLLVE DKTNQKYLLT KTLRVDSEDS TTCQLYVLRE
     EPPSTGFGVK QEAEFSTPHR VSSDPLSSEN LSSAVGQKIA SPNRMLSDEN SYATIIVGFP
     DLMSPNEVYS WKRPSSLQKP RGTDIAFYGG KKRGTPKHSN CVTLLETNQV VRILPPGDVP
     LRDIYAKDVT PPQTAGYIEV TDLQSKKLRY IPIPSSESLS PYTTWLSSIS DTDALLTEWG
     TGGVVTVDMG GRVRLWETGL EHLQRSLMEW KTMIGQEGVR DMQITVNRDS GEDVSSPKHG
     KEDPDNMPHV GGNMWAGGTG GRDTAGLGGK GGPYRLDVGH TVYQVSEVEK DAVPEEVKRA
     AREMGQRAFQ QRLKEIQMSE YDAASYERFS GAVRRQVHSL RIILDNLQAK GKERQWLRHQ
     AMGELDDAKI IDGLTGEKAI YKRRGDLEPQ MGSPQQKPKR LRLVVDVSGS MYRFNGVDSR
     LERSLEAVCM VMEAFENYEE KFKYDITGHS GDGYNISLVP INKIPKDNKQ RLEILKTMHA
     HAQFCMSGDH TLEGTEHAIK DIVKEEADEY FVIVLSDANL SRYGIHPTKF AQILTSNPQV
     NAFAIFIGSL GDQATRLQQT LPAGRSFVAM DTRDIPQILQ QIFTSTMLST V
//