ID A0A1S3A4I3_ERIEU Unreviewed; 518 AA.
AC A0A1S3A4I3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Inositol-pentakisphosphate 2-kinase {ECO:0000256|ARBA:ARBA00014846, ECO:0000256|RuleBase:RU364126};
DE EC=2.7.1.158 {ECO:0000256|ARBA:ARBA00012023, ECO:0000256|RuleBase:RU364126};
GN Name=IPPK {ECO:0000313|RefSeq:XP_007529252.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007529252.1};
RN [1] {ECO:0000313|RefSeq:XP_007529252.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form
CC Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). {ECO:0000256|RuleBase:RU364126}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-
CC inositol hexakisphosphate + ADP + H(+); Xref=Rhea:RHEA:20313,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57733,
CC ChEBI:CHEBI:58130, ChEBI:CHEBI:456216; EC=2.7.1.158;
CC Evidence={ECO:0000256|RuleBase:RU364126};
CC -!- DOMAIN: The EXKPK motif is conserved in inositol-pentakisphosphate 2-
CC kinases of both family 1 and 2. {ECO:0000256|RuleBase:RU364126}.
CC -!- SIMILARITY: Belongs to the IPK1 type 2 family.
CC {ECO:0000256|ARBA:ARBA00007229}.
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DR RefSeq; XP_007529252.1; XM_007529190.2.
DR AlphaFoldDB; A0A1S3A4I3; -.
DR CTD; 64768; -.
DR eggNOG; KOG4749; Eukaryota.
DR InParanoid; A0A1S3A4I3; -.
DR OrthoDB; 8233at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0035299; F:inositol pentakisphosphate 2-kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.200.110; Inositol-pentakisphosphate 2-kinase, N-lobe; 1.
DR InterPro; IPR009286; Ins_P5_2-kin.
DR InterPro; IPR043001; IP5_2-K_N_lobe.
DR PANTHER; PTHR14456; INOSITOL POLYPHOSPHATE KINASE 1; 1.
DR PANTHER; PTHR14456:SF2; INOSITOL-PENTAKISPHOSPHATE 2-KINASE; 1.
DR Pfam; PF06090; Ins_P5_2-kin; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU364126};
KW Kinase {ECO:0000256|RuleBase:RU364126};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364126};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU364126}.
SQ SEQUENCE 518 AA; 57805 MW; 07E18DEE0E36F389 CRC64;
MDEAKMDENE WRYHGEGNKS LVVAHAQVSG GRPSAASPPP GRCRVLPCRE LAEGPGASGG
AGAWGAPCLG CSQPPRTKFH LGKVPGIALA AAAAVLTRHR AQEVVQLPLD FVKQLCLKIQ
PERPESRCDK DLDTLSGYAL CLPNLARLQT YHFAEHRPIL CVEIKPKCGF IPFSSDVTHE
MKHKVCRYCM HQHLKVANGK WKQISKYCPL DLYSGNKQRM HFALKSLLQE AQNNLKIFKN
GELIYGCKDS RSPAADWSEL AHHLKPFFFP SNGLASGPHC TRAVIRELVR VITRVLLSGS
DKDRLGTLRP GPELQGPRVC EASPFGRSLR HQGKAPLEHS GLPKGCLLYR TLQVQMLDLL
DIEGLYPLYR RVERYLEEFP EERKALQIDG PYDEAFYQKL LDLSTEDDGT VAFALKKVQQ
YRVAMTAKDC SIMIALSPCL QDASPDQRPI VPSSRSRFAF SVSVLDLDLK PYESIPHQYT
LDGKIVSYYS KAARAKDAAV MSTRFKESED CTLVLHKV
//
