ID A0A1S3A5L7_ERIEU Unreviewed; 654 AA.
AC A0A1S3A5L7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Phosphatidylinositol-binding clathrin assembly protein isoform X4 {ECO:0000313|RefSeq:XP_007529751.1};
GN Name=PICALM {ECO:0000313|RefSeq:XP_007529751.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007529751.1};
RN [1] {ECO:0000313|RefSeq:XP_007529751.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PICALM/SNAP91 family.
CC {ECO:0000256|ARBA:ARBA00008011}.
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DR RefSeq; XP_007529751.1; XM_007529689.2.
DR AlphaFoldDB; A0A1S3A5L7; -.
DR STRING; 9365.ENSEEUP00000012723; -.
DR GeneID; 103119418; -.
DR CTD; 8301; -.
DR eggNOG; KOG0251; Eukaryota.
DR OrthoDB; 3667239at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:InterPro.
DR GO; GO:0005545; F:1-phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0048268; P:clathrin coat assembly; IEA:InterPro.
DR GO; GO:0072583; P:clathrin-dependent endocytosis; IEA:InterPro.
DR CDD; cd16985; ANTH_N_AP180; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 1.20.58.150; ANTH domain; 1.
DR InterPro; IPR011417; ANTH_dom.
DR InterPro; IPR014712; ANTH_dom_sf.
DR InterPro; IPR045192; AP180-like.
DR InterPro; IPR013809; ENTH.
DR InterPro; IPR008942; ENTH_VHS.
DR PANTHER; PTHR22951; CLATHRIN ASSEMBLY PROTEIN; 1.
DR PANTHER; PTHR22951:SF16; PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN; 1.
DR Pfam; PF07651; ANTH; 1.
DR SMART; SM00273; ENTH; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50942; ENTH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000079721}.
FT DOMAIN 14..145
FT /note="ENTH"
FT /evidence="ECO:0000259|PROSITE:PS50942"
FT REGION 557..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 321..348
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 654 AA; 71112 MW; 1A1822A0180F4C9A CRC64;
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT
TLSNAVSSLA NTGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP
VSASAGVIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPLSS TSQVASTWGD
PFSATVDAVD DAIPRLNPFL TKSSGDVHLP ISSDVSTFTT RTPTHEMFVG FTPSPVSQPQ
PHPSAGLNVD FESVFGNKST NVIVDTGGFD ELGGLLKPTV ASQNQSLPVA KLPPNKLVSD
DLDSSLANLV GNLGIGNGTS KNDVNWSQPG EKKLTGGSNW QPKVAPTTAW NAATMAPPVM
AYPATTPTGM IGYGIPPQMG SVPVMTQPTL IYSQPVMRPP NPFGPVSGAQ IQFM
//
