ID A0A1S3A5Z4_ERIEU Unreviewed; 350 AA.
AC A0A1S3A5Z4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Thrombopoietin isoform X4 {ECO:0000313|RefSeq:XP_007529861.1};
GN Name=THPO {ECO:0000313|RefSeq:XP_007529861.1};
OS Erinaceus europaeus (Western European hedgehog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Erinaceidae; Erinaceinae;
OC Erinaceus.
OX NCBI_TaxID=9365 {ECO:0000313|Proteomes:UP000079721, ECO:0000313|RefSeq:XP_007529861.1};
RN [1] {ECO:0000313|RefSeq:XP_007529861.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the EPO/TPO family.
CC {ECO:0000256|ARBA:ARBA00005782}.
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DR RefSeq; XP_007529861.1; XM_007529799.2.
DR AlphaFoldDB; A0A1S3A5Z4; -.
DR STRING; 9365.ENSEEUP00000012311; -.
DR GeneID; 103119495; -.
DR CTD; 7066; -.
DR eggNOG; ENOG502S9T0; Eukaryota.
DR InParanoid; A0A1S3A5Z4; -.
DR OrthoDB; 5347971at2759; -.
DR Proteomes; UP000079721; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0008283; P:cell population proliferation; IEA:InterPro.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR001323; EPO_TPO.
DR InterPro; IPR003978; Thrombopoietin.
DR PANTHER; PTHR10560; THROMBOPOIETIN; 1.
DR PANTHER; PTHR10560:SF0; THROMBOPOIETIN; 1.
DR Pfam; PF00758; EPO_TPO; 1.
DR PRINTS; PR01485; THROMBOPTN.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000079721};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..350
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010237217"
SQ SEQUENCE 350 AA; 36901 MW; E1ADDD251F1B982F CRC64;
MELTELLLVV IPLLTARPTL SSSAPPACDP RLLNKLLRDS QALHSRLSQC PDARLLPTPV
LLPTVDFSLG EWKAQTEQNK AQDVLGASAL LLEGVMAARG QLGPSCLSAL LGQLSGQVRL
LLGALQGLLG TQLPPQGRTI AHEDPSAIFL NFQQLLRGKV RFLLLVVGPT LCAKRALPST
DAPGSTSLFL TLNNRTAGWL ETNADISART TGSGLLKRLQ GLRAKTPGLQ SQTLRSPGQT
PAHLNRTRGP LNGTHGLFPG SFSRVQGALG IPSGTLDTGS LPPNLQPGYS ASLTQTAAGL
HTLFPPSAMV PTPTVQLQPL FPDPSASMPS PTSPLQIAAH THFQNSSQEE
//
